Title:
PROCESS FOR THE PRODUCTION OF R(+) alpha -LIPOIC ACID
Document Type and Number:
WIPO Patent Application WO2002030918
Kind Code:
A3
Abstract:
Process for the synthesis of R(+) alpha -lipoic acid comprising the following stages: a) Salifying of racemic thioctic acid with R(+) alpha -methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt of R(+) alpha -lipoic acid-R(+) alpha -methylbenzylamine; c) purification by re-crystallization of the diastereoisomeric salt of R(+) alpha -lipoic acid-R(+) alpha -methylbenzylamine, in which the re-crystallization solvent consists of a mixture of non-polar/polar solvents; d) separation of the diastereoisomeric salt to obtain R(+) alpha -lipoic acid by reaction of said salt with acids selected from the group consisting of aliphatic hydroxy-carboxylic acids having 3 to 6 carbon atoms and aqueous phosphoric acid.
Inventors:
VILLANI FLAVIO (IT)
NARDI ANTONIO (IT)
SALVI ANNIBALE (IT)
FALABELLA GIOVANNA (IT)
NARDI ANTONIO (IT)
SALVI ANNIBALE (IT)
FALABELLA GIOVANNA (IT)
Application Number:
PCT/EP2001/011575
Publication Date:
August 01, 2002
Filing Date:
October 08, 2001
Export Citation:
Assignee:
LABORATORIO CHIMICO INT SPA (IT)
VILLANI FLAVIO (IT)
NARDI ANTONIO (IT)
SALVI ANNIBALE (IT)
FALABELLA GIOVANNA (IT)
VILLANI FLAVIO (IT)
NARDI ANTONIO (IT)
SALVI ANNIBALE (IT)
FALABELLA GIOVANNA (IT)
International Classes:
C07B57/00; C07C319/06; C07D339/04; C07C323/60; (IPC1-7): C07D339/04; C07D319/06
Foreign References:
| US5281722A | 1994-01-25 | |||
| EP0702953A2 | 1996-03-27 | |||
| FR4630M | 1966-11-28 | |||
| US5621117A | 1997-04-15 |
Other References:
TETRAHEDRON: ASYMMETRY, vol. 5, no. 1, 1994, Great Britan, pages 5 - 8, XP002199866
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