Title:
PAI-1 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2009/125606
Kind Code:
A1
Abstract:
Provided is a compound represented by formula (I) having a PAI-1 inhibiting action. [In formula (I), R1 represents an optionally substituted C6-10 aryl group etc., T represents a single bond etc., m is 0 or 1, when m is 0 G represents -N-C(=O)-CO2H etc., when m is 1 G represents an oxygen atom etc., R2 represents an optionally substituted C6-10 aryl group etc, E represents formula (II) (wherein one of R31, R32, R33 and R34 represents R1-T- and the remaining three each individually represent a hydrogen atom etc., and R35 is -X-Y', a hydrogen atom etc.), X represents -CH2- etc., Y' represents a carboxyl group etc. and M represents a single bond etc.]
Inventors:
YAMAGUCHI YOUICHI (JP)
YANASE TAKESHI (JP)
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
YANASE TAKESHI (JP)
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
Application Number:
PCT/JP2009/001695
Publication Date:
October 15, 2009
Filing Date:
April 13, 2009
Export Citation:
Assignee:
INST MED MOLECULAR DESIGN INC (JP)
YAMAGUCHI YOUICHI (JP)
YANASE TAKESHI (JP)
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
YAMAGUCHI YOUICHI (JP)
YANASE TAKESHI (JP)
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
International Classes:
C07C59/66; A61K31/192; A61K31/196; A61K31/197; A61K31/36; A61K31/402; A61K31/41; A61K31/4453; A61K31/451; A61K31/495; A61K31/54; A61K31/55; C07C59/68; C07C59/70; C07C65/24; C07C205/56; C07C229/42; C07C233/25; C07C233/56; C07C311/08; C07C311/29; C07C317/22; C07C323/12; C07C323/21; C07C323/22; C07C323/41; C07C323/62; C07D211/42; C07D257/04; C07D295/12; C07D317/54
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Other References:
JAIN.M.R. ET AL.: "PAI-1 inhibitory activity of oxalamide derivatives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, 2008, pages 880 - 884, XP022576492
STOKES, N.R. ET AL.: "Novel Inhibitors of Bacterial Cytokinesis Indentified by a Cell-based Antibiotic Screening Assay", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 48, 2005, pages 39709 - 39715, XP008143582
TSUCHIDA, K. ET AL.: "Discovery of Nonpeptidic Small-Molecule AP-1 Inhibitors: Lead Hopping Based on a Three-Dimensional Pharmacophore Model", J. MED. CHEM., vol. 49, 2006, pages 80 - 91, XP002421897
See also references of EP 2272817A4
PROC. NATL. ACAD. SCI. USA, vol. 89, no. 15, 1992, pages 6998 - 7002
NATURE, vol. 346, no. 6279, 1990, pages 74 - 76
MOL. MED., vol. 2, no. 5, 1996, pages 568 - 582
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GEN. DIAGN. PATHOL., vol. 141, no. 1, 1995, pages 41 - 48
NAT. MED., vol. 4, no. 8, 1998, pages 923 - 928
J. IMMUNOL., vol. 165, no. 6, 2000, pages 3154 - 3161
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 294, no. 5, 2002, pages 1155 - 1160
BIOCHEMISTRY, vol. 37, no. 5, 1998, pages 1227 - 1234
J. MED CHEM., vol. 47, no. 14, 2004, pages 3491 - 3494
MUKUL R. JAIN ET AL., EUR. J. MED CHEM., vol. 43, no. 4, 2008, pages 880 - 884
T. W. GREENE; P. G. M. WUTS: "Protective Groups in Organic Synthesis", 1999
J. ORG. CHEM., vol. 55, no. 15, 1990, pages 4622 - 4634
STOKES, N.R. ET AL.: "Novel Inhibitors of Bacterial Cytokinesis Indentified by a Cell-based Antibiotic Screening Assay", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 48, 2005, pages 39709 - 39715, XP008143582
TSUCHIDA, K. ET AL.: "Discovery of Nonpeptidic Small-Molecule AP-1 Inhibitors: Lead Hopping Based on a Three-Dimensional Pharmacophore Model", J. MED. CHEM., vol. 49, 2006, pages 80 - 91, XP002421897
See also references of EP 2272817A4
PROC. NATL. ACAD. SCI. USA, vol. 89, no. 15, 1992, pages 6998 - 7002
NATURE, vol. 346, no. 6279, 1990, pages 74 - 76
MOL. MED., vol. 2, no. 5, 1996, pages 568 - 582
FASEB J., vol. 15, no. 10, 2001, pages 1840 - 1842
GEN. DIAGN. PATHOL., vol. 141, no. 1, 1995, pages 41 - 48
NAT. MED., vol. 4, no. 8, 1998, pages 923 - 928
J. IMMUNOL., vol. 165, no. 6, 2000, pages 3154 - 3161
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 294, no. 5, 2002, pages 1155 - 1160
BIOCHEMISTRY, vol. 37, no. 5, 1998, pages 1227 - 1234
J. MED CHEM., vol. 47, no. 14, 2004, pages 3491 - 3494
MUKUL R. JAIN ET AL., EUR. J. MED CHEM., vol. 43, no. 4, 2008, pages 880 - 884
T. W. GREENE; P. G. M. WUTS: "Protective Groups in Organic Synthesis", 1999
J. ORG. CHEM., vol. 55, no. 15, 1990, pages 4622 - 4634
Attorney, Agent or Firm:
ISSHIKI & CO. (JP)
All international patent business corporation (JP)
All international patent business corporation (JP)
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