Title:
PAIR OF POLYKETIDE COMPOUNDS HAVING ANTI-INFLAMMATORY ACTIVITY, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/240679
Kind Code:
A1
Abstract:
The present invention relates to the technical field of medicines, and disclosed are a pair of polyketide compounds having anti-inflammatory activity, a preparation method therefor, and a use thereof. Specifically, endophytic fungus Alternaria sp. HJT-Y7 is separated and obtained from leaf parts collected from Rhodiola tibetica, the obtained endophytic fungus Alternaria sp. HJT-Y7 is subjected to solid fermentation, then two new polyketone compounds are separated and obtained by means of a series of separation and purification methods, and the two polyketone compounds both have good anti-inflammatory activity, thereby providing a new way for development of anti-inflammatory drugs.
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Inventors:
LU XUAN (CN)
TANG XIAOYUAN (CN)
TANG CHUAN (CN)
FENG WEIXING (CN)
FENG BAOMIN (CN)
TANG XIAOYUAN (CN)
TANG CHUAN (CN)
FENG WEIXING (CN)
FENG BAOMIN (CN)
Application Number:
PCT/CN2022/101720
Publication Date:
December 21, 2023
Filing Date:
June 28, 2022
Export Citation:
Assignee:
UNIV DALIAN (CN)
International Classes:
A61K31/335; C07D313/08; A61P29/00; C12N1/14; C12P17/08; C12R1/645
Foreign References:
| CN113277998A | 2021-08-20 | |||
| CN113248369A | 2021-08-13 | |||
| CN112592327A | 2021-04-02 | |||
| CN108315264A | 2018-07-24 | |||
| CN105503808A | 2016-04-20 | |||
| CN108265007A | 2018-07-10 |
Attorney, Agent or Firm:
DALIAN EAST PATENT AGENT LTD. (CN)
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