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Patent Searching and Data


Title:
PAN-KRAS INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2024/012519
Kind Code:
A1
Abstract:
Provided in the present invention are a fused ring aromatic compound having a broad-spectrum inhibition effect on KRAS mutation, and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof. As shown in formula (I), the definition of each group in the formula is detailed in the description. In addition, further disclosed in the present invention are a pharmaceutical composition containing the compound and the use thereof in the preparation of a kit for treating diseases such as cancer and immunity or evaluating the prognosis of patients with diseases such as cancer and immunity.

Inventors:
LIU XIAOHUI (CN)
WANG YANFENG (CN)
WU MEIFENG (CN)
FENG XUERONG (CN)
ZENG LIAN (CN)
ZOU PINJU (CN)
WANG YEYE (CN)
YU XIAOHUI (CN)
Application Number:
PCT/CN2023/107172
Publication Date:
January 18, 2024
Filing Date:
July 13, 2023
Export Citation:
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Assignee:
BEIJING PHARSCIN INNOBIO CO LTD (CN)
International Classes:
A61K31/495; C07D519/00; A61P35/00; C07D471/04; C07D487/04
Domestic Patent References:
WO2023061294A12023-04-20
WO2023020519A12023-02-23
WO2023097227A12023-06-01
WO2023020523A12023-02-23
WO2023018812A12023-02-16
WO2023018809A12023-02-16
WO2023274324A12023-01-05
WO2022256459A12022-12-08
WO2022248885A22022-12-01
WO2022247760A12022-12-01
WO2022237649A12022-11-17
WO2022132200A12022-06-23
WO2022042630A12022-03-03
Attorney, Agent or Firm:
MERITS IP LTD. (CN)
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