Title:
PAN-KRAS INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2024/012519
Kind Code:
A1
Abstract:
Provided in the present invention are a fused ring aromatic compound having a broad-spectrum inhibition effect on KRAS mutation, and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof. As shown in formula (I), the definition of each group in the formula is detailed in the description. In addition, further disclosed in the present invention are a pharmaceutical composition containing the compound and the use thereof in the preparation of a kit for treating diseases such as cancer and immunity or evaluating the prognosis of patients with diseases such as cancer and immunity.
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Inventors:
LIU XIAOHUI (CN)
WANG YANFENG (CN)
WU MEIFENG (CN)
FENG XUERONG (CN)
ZENG LIAN (CN)
ZOU PINJU (CN)
WANG YEYE (CN)
YU XIAOHUI (CN)
WANG YANFENG (CN)
WU MEIFENG (CN)
FENG XUERONG (CN)
ZENG LIAN (CN)
ZOU PINJU (CN)
WANG YEYE (CN)
YU XIAOHUI (CN)
Application Number:
PCT/CN2023/107172
Publication Date:
January 18, 2024
Filing Date:
July 13, 2023
Export Citation:
Assignee:
BEIJING PHARSCIN INNOBIO CO LTD (CN)
International Classes:
C07D519/00; A61K31/495; A61P35/00; C07D471/04; C07D487/04
Domestic Patent References:
| WO2023061294A1 | 2023-04-20 | |||
| WO2023020519A1 | 2023-02-23 | |||
| WO2023097227A1 | 2023-06-01 | |||
| WO2023020523A1 | 2023-02-23 | |||
| WO2023018812A1 | 2023-02-16 | |||
| WO2023018809A1 | 2023-02-16 | |||
| WO2023274324A1 | 2023-01-05 | |||
| WO2022256459A1 | 2022-12-08 | |||
| WO2022248885A2 | 2022-12-01 | |||
| WO2022247760A1 | 2022-12-01 | |||
| WO2022237649A1 | 2022-11-17 | |||
| WO2022132200A1 | 2022-06-23 | |||
| WO2022042630A1 | 2022-03-03 |
Attorney, Agent or Firm:
MERITS IP LTD. (CN)
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