Title:
PARASPORIN EXPRESSION VECTOR AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2024/014560
Kind Code:
A1
Abstract:
Provided are: an expression vector into which a gene encoding parasporin (hereinafter, referred to as "PS") is inserted and with which a pharmaceutical composition applicable to the treatment of cancer can be achieved; a cell into which the expression vector is introduced; a method for expressing PS; a pharmaceutical composition; and a transformant. This expression vector contains a gene encoding parasporin. This expression vector includes a viral vector into which a gene is inserted, wherein the viral vector is expressed as a PS protein. A gene encoding the PS protein is the whole or part of a PS gene, and includes a PS-like gene encoding a protein, which does not have hemolysis against red blood cells and exhibits selective cytotoxicity to cancer cells, among Cry proteins that produce Bt bacteria and/or Bt bacteria-related cells.
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Inventors:
HARA KENICHIRO (JP)
SAGARA MIYAKO (JP)
TANI KENZABURO (JP)
MIYAMOTO SHOHEI (JP)
SAGARA MIYAKO (JP)
TANI KENZABURO (JP)
MIYAMOTO SHOHEI (JP)
Application Number:
PCT/JP2023/026163
Publication Date:
January 18, 2024
Filing Date:
July 15, 2023
Export Citation:
Assignee:
NPT CO LTD (JP)
UNIV TOKYO (JP)
UNIV TOKYO (JP)
International Classes:
C12N15/63; A61K48/00; A61P35/00; A61P43/00; C07K14/32; C12N5/10; C12N15/31; C12N15/85; C12N15/86; C12P21/02
Domestic Patent References:
| WO2018194089A1 | 2018-10-25 |
Foreign References:
| JP2018070565A | 2018-05-10 | |||
| JP2018177656A | 2018-11-15 | |||
| JP2010227014A | 2010-10-14 | |||
| JP2005263728A | 2005-09-29 |
Other References:
J.F. DE GRAAF, ET AL.: "Armed oncolytic viruses: A kick-start for anti-tumor immunity", CYTOKINE & GROWTH FACTOR REVIEWS, ELSEVIER LTD, GB, vol. 41, 19 March 2018 (2018-03-19), GB , pages 28 - 39, XP055580278, ISSN: 1359-6101, DOI: 10.1016/j.cytogfr.2018.03.006
Attorney, Agent or Firm:
OHNO Koushu (JP)
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