Title:
PARATHYROID GLAND CELLS
Document Type and Number:
WIPO Patent Application WO/2022/071334
Kind Code:
A1
Abstract:
The present invention provides a means for producing a parathyroid gland organoid. A culture method according to the present invention includes: a cell mass containing parathyroid gland cells at a content ratio of 50% or more and mesenchymal cells at a content ratio of 10% or more; and a step for culturing the cell mass in a culture medium.
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Inventors:
TAKEBE TAKANORI (JP)
SAIKI NORIKAZU (JP)
SAIKI NORIKAZU (JP)
Application Number:
PCT/JP2021/035681
Publication Date:
April 07, 2022
Filing Date:
September 28, 2021
Export Citation:
Assignee:
UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP)
TAKEDA PHARMACEUTICALS CO (JP)
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C12N5/077; A61K35/55; A61L27/36; A61P5/18; C12M1/00; G01N33/15; G01N33/50
Domestic Patent References:
| WO2013047720A1 | 2013-04-04 |
Foreign References:
| JP2013524836A | 2013-06-20 | |||
| JP2021069345A | 2021-05-06 |
Other References:
BETTY R LAWTON, CORINE MARTINEAU, JULIE ANN SOSA, SANZIANA ROMAN, COURTNEY E GIBSON, MICHAEL A LEVINE, DIANE S KRAUSE: "Differentiation of PTH-Expressing Cells From Human Pluripotent Stem Cells", ENDOCRINOLOGY, vol. 161, no. 10, 18 August 2020 (2020-08-18), US , XP009535517, ISSN: 0013-7227, DOI: 10.1210/endocr/bqaa141
PARK YOON SHIN; HWANG JI-YOUNG; JUN YESL; JIN YOON MI; KIM GYUNGAH; KIM HA YEONG; KIM HAN SU; LEE SANG-HOON; JO INHO: "Scaffold-free parathyroid tissue engineering using tonsil-derived mesenchymal stem cells", ACTA BIOMATERIALIA, ELSEVIER, AMSTERDAM, NL, vol. 35, 2 March 2016 (2016-03-02), AMSTERDAM, NL, pages 215 - 227, XP029498949, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2016.03.003
PARK YOON SHIN, KIM HAN SU, JIN YOON MI, YU YEONSIL, KIM HA YEONG, PARK HAE SANG, JUNG SUNG-CHUL, HAN KI-HWAN, RYU KYUNG-HA, JO IN: "Differentiated tonsil-derived mesenchymal stem cells embedded in Matrigel restore parathyroid cell functions in rats with parathyroidectomy", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 65, 1 October 2015 (2015-10-01), AMSTERDAM, NL , pages 140 - 152, XP055919121, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2015.06.044
PARK ET AL.: "Scaffold-free parathyroid tissue engineering using tonsil-derived mesenchymal stem cells", ACTA BIOMATERIALIA, vol. 35, 15 April 2016 (2016-04-15), pages 215 - 227, XP029498949, DOI: 10.1016/j.actbio.2016.03.003
KANAI ET AL.: "Suppression of parathyroid hormone production in vitro and in vivo by RNA interference", KIDNEY INTERNATIONAL, vol. 75, 2009, pages 490 - 498
"Institutional Biosafety Committee, Office of Research", UNIVERSITY OF CALIFORNIA, article "Derivation of Parathyroid Gland Cells and Their Progenitors from Induced Pluripotent Stem Cells (iPSCs) for Personalized Therapy"
CELL REPORTS, vol. 2, 2012, pages 553 - 567
PLOS ONE, vol. 8, no. 4, 2013, pages e59243
NAT BIOTECHNOL., vol. 32, no. 6, 2014, pages 554 - 61
SCI REP., vol. 6, 2016, pages 35680
NAT CELL BIOL, vol. 17, no. 8, 2015, pages 994 - 1003
CELL REP., vol. 21, no. 10, 2017, pages 2661 - 2670
PARK YOON SHIN; HWANG JI-YOUNG; JUN YESL; JIN YOON MI; KIM GYUNGAH; KIM HA YEONG; KIM HAN SU; LEE SANG-HOON; JO INHO: "Scaffold-free parathyroid tissue engineering using tonsil-derived mesenchymal stem cells", ACTA BIOMATERIALIA, ELSEVIER, AMSTERDAM, NL, vol. 35, 2 March 2016 (2016-03-02), AMSTERDAM, NL, pages 215 - 227, XP029498949, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2016.03.003
PARK YOON SHIN, KIM HAN SU, JIN YOON MI, YU YEONSIL, KIM HA YEONG, PARK HAE SANG, JUNG SUNG-CHUL, HAN KI-HWAN, RYU KYUNG-HA, JO IN: "Differentiated tonsil-derived mesenchymal stem cells embedded in Matrigel restore parathyroid cell functions in rats with parathyroidectomy", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 65, 1 October 2015 (2015-10-01), AMSTERDAM, NL , pages 140 - 152, XP055919121, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2015.06.044
PARK ET AL.: "Scaffold-free parathyroid tissue engineering using tonsil-derived mesenchymal stem cells", ACTA BIOMATERIALIA, vol. 35, 15 April 2016 (2016-04-15), pages 215 - 227, XP029498949, DOI: 10.1016/j.actbio.2016.03.003
KANAI ET AL.: "Suppression of parathyroid hormone production in vitro and in vivo by RNA interference", KIDNEY INTERNATIONAL, vol. 75, 2009, pages 490 - 498
"Institutional Biosafety Committee, Office of Research", UNIVERSITY OF CALIFORNIA, article "Derivation of Parathyroid Gland Cells and Their Progenitors from Induced Pluripotent Stem Cells (iPSCs) for Personalized Therapy"
CELL REPORTS, vol. 2, 2012, pages 553 - 567
PLOS ONE, vol. 8, no. 4, 2013, pages e59243
NAT BIOTECHNOL., vol. 32, no. 6, 2014, pages 554 - 61
SCI REP., vol. 6, 2016, pages 35680
NAT CELL BIOL, vol. 17, no. 8, 2015, pages 994 - 1003
CELL REP., vol. 21, no. 10, 2017, pages 2661 - 2670
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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