Title:
PARKINSON'S DISEASE IN-VITRO DIAGNOSTIC KIT BASED ON DNA HEXAHEDRON AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/098369
Kind Code:
A1
Abstract:
Disclosed herein are an isolated microRNA molecule, a Parkinson's disease in-vitro diagnostic kit based on a DNA hexahedron, and use thereof. The microRNA molecule miR26690 provided by the present application is highly expressed in an exosome in peripheral blood of a patient with Parkinson's disease, and can be used for in-vitro diagnosis and/or screening of Parkinson's disease. In addition, the kit and method for detecting the miR26690 in the peripheral blood can detect the miR26690 in the peripheral blood with high sensitivity and high specificity, and are used for diagnosing Parkinson's disease; compared with a traditional Parkinson's disease marker detection method, the method is simple, and features easy preparation, a small amount of detected samples, higher sensitivity, a low limit of detection, and a low detection cost.
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Inventors:
YU ZHENWEI (CN)
ZHENG YUANCHU (CN)
FENG TAO (CN)
ZHENG YUANCHU (CN)
FENG TAO (CN)
Application Number:
PCT/CN2022/131321
Publication Date:
May 16, 2024
Filing Date:
November 11, 2022
Export Citation:
Assignee:
BEIJING NERUOSURGICAL INST (CN)
International Classes:
C12N15/113; C12N15/11; C12Q1/6816; C12Q1/6883
Foreign References:
| CN114214404A | 2022-03-22 | |||
| CN113388668A | 2021-09-14 | |||
| CN113454240A | 2021-09-28 | |||
| KR20150139096A | 2015-12-11 |
Other References:
TU HUAIJUN: "To Explore Preliminarily the Diagnosistic Value of microRNA Expressiohn Profile of Plasma Exosomes for Patients with Parkinson’s Disease", MEDICAL AND HEALTH SCIENCES, CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, 1 December 2016 (2016-12-01), XP093170140
IDA MANNA ET AL.: "Exosomal miRNA as peripheral biomarkers in Parkinson's disease and progressive supranuclear palsy: A pilot study", PARKINSONISM RELAT DISORD., vol. 93, no. 12, 24 November 2021 (2021-11-24), XP086899730, DOI: 10.1016/j.parkreldis.2021.11.020
MAO DONGSHENG; ZHENG MENGMENG; LI WENXING; XU YI; WANG CHENGGUANG; QIAN QIULING; LI SHUAINAN; CHEN GUIFANG; ZHU XIAOLI; MI XIANQIA: "Cubic DNA nanocage-based three-dimensional molecular beacon for accurate detection of exosomal miRNAs in confined spaces", BIOSENSORS AND BIOELECTRONICS, ELSEVIER SCIENCE LTD, UK, AMSTERDAM , NL, vol. 204, 12 February 2022 (2022-02-12), Amsterdam , NL , XP086988167, ISSN: 0956-5663, DOI: 10.1016/j.bios.2022.114077
IDA MANNA ET AL.: "Exosomal miRNA as peripheral biomarkers in Parkinson's disease and progressive supranuclear palsy: A pilot study", PARKINSONISM RELAT DISORD., vol. 93, no. 12, 24 November 2021 (2021-11-24), XP086899730, DOI: 10.1016/j.parkreldis.2021.11.020
MAO DONGSHENG; ZHENG MENGMENG; LI WENXING; XU YI; WANG CHENGGUANG; QIAN QIULING; LI SHUAINAN; CHEN GUIFANG; ZHU XIAOLI; MI XIANQIA: "Cubic DNA nanocage-based three-dimensional molecular beacon for accurate detection of exosomal miRNAs in confined spaces", BIOSENSORS AND BIOELECTRONICS, ELSEVIER SCIENCE LTD, UK, AMSTERDAM , NL, vol. 204, 12 February 2022 (2022-02-12), Amsterdam , NL , XP086988167, ISSN: 0956-5663, DOI: 10.1016/j.bios.2022.114077
Attorney, Agent or Firm:
MERITS IP LTD. (CN)
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