Title:
PARTIAL DOPAMINE-D2 RECEPTOR AGONIST PLUS SEROTONIN AND/ODER NORADRENALINE INHIBITOR ACTIVITY
Document Type and Number:
WIPO Patent Application WO2003068207
Kind Code:
A3
Abstract:
The invention relates to the use of a compound or a combination of compounds having partial dopamine-D2 receptor agonistic activity and serotonin and/or noradrenaline reuptake inhibitory activity, for the preparation of a pharmaceutical composition for the treatment of psychiatric and/or neurologic disorders caused by disturbances of the major monoaminergic (dopamine, serotonin and/or nordrenaline) systems or that can be treated via manipulation of those systems.
Inventors:
BRONZOVA JULIANA B (NL)
FEENSTRA ROELOF W (NL)
GLENNON JEFFREY C (NL)
MCCREARY ANDREW C (NL)
VAN RANDEN JAN (NL)
RONKEN ERIC (NL)
VAN SCHARRENBURG GUSTAAF J M (NL)
FEENSTRA ROELOF W (NL)
GLENNON JEFFREY C (NL)
MCCREARY ANDREW C (NL)
VAN RANDEN JAN (NL)
RONKEN ERIC (NL)
VAN SCHARRENBURG GUSTAAF J M (NL)
Application Number:
PCT/EP2003/050015
Publication Date:
December 18, 2003
Filing Date:
February 11, 2003
Export Citation:
Assignee:
SOLVAY PHARM BV (NL)
BRONZOVA JULIANA B (NL)
FEENSTRA ROELOF W (NL)
GLENNON JEFFREY C (NL)
MCCREARY ANDREW C (NL)
VAN RANDEN JAN (NL)
RONKEN ERIC (NL)
VAN SCHARRENBURG GUSTAAF J M (NL)
BRONZOVA JULIANA B (NL)
FEENSTRA ROELOF W (NL)
GLENNON JEFFREY C (NL)
MCCREARY ANDREW C (NL)
VAN RANDEN JAN (NL)
RONKEN ERIC (NL)
VAN SCHARRENBURG GUSTAAF J M (NL)
International Classes:
A61K31/00; A61K31/138; A61K31/445; A61K31/48; A61K31/495; A61K31/535; A61K31/55; A61K45/00; A61K45/06; A61P25/00; A61P25/14; A61P25/18; A61P25/22; A61P25/24; A61P43/00; (IPC1-7): A61K31/138; A61K31/495; A61K31/445; A61K31/535; A61K31/55; A61K31/48; A61P25/00
Domestic Patent References:
| WO2001014330A2 | 2001-03-01 | |||
| WO2000029397A1 | 2000-05-25 |
Other References:
HINDMARCH I: "THE EFFECTS OF ANTIDEPRESSANTS ON PSYCHOMOTOR FUNCTION WITH PARTICULAR REFERENCE TO REBOXETINE", EUROPEAN NEUROPSYCHOPHARMACOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, AMSTERDAM, NL, vol. SUPPL. 1, no. 7, April 1997 (1997-04-01), pages S17 - S21,S71-S73, XP001079967, ISSN: 0924-977X
JOHNSTON L C ET AL: "THE NOVEL DOPAMINE D2 RECEPTOR PARTIAL AGONIST, SLV-308, REVERSES MOTOR DISABILITY IN MPTP-LESIONED COMMON MARMOSETS (CALLITHRIXJACCHUS)", BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, vol. SUPPL, no. 133, May 2001 (2001-05-01), pages U - 70,AN134P, XP001061442, ISSN: 0007-1188
OLBRICH R ET AL: "AN EVALUATION OF THE PARTIAL DOPAMINE AGONIST TERGURIDE REGARDING POSITIVE SYMPTOMS REDUCTION IN SCHIZOPHRENICS", JOURNAL OF NEURAL TRANSMISSION, SPRINGER VERLAG, VIENNA, AT, vol. 3, no. 84, 1991, pages 233 - 236, XP001061450, ISSN: 0300-9564
LATHI A.C. ET AL: "Antipsychotic properties of the partial dopamine agonist (-)-3-(3-hydroxyphenyl)-N-N-propylpiperidine (Preclamol) in schizophrenia", BIOLOGICAL PSYCHIATRY, vol. 43, no. 1, 1998, pages 2 - 11, XP001079970
FURLAN P M ET AL: "COGNITIVE AND PSYCHOMOTOR EFFECTS OF PAROXETINE AND SERTRALINE ON HEALTHY ELDERLY VOLUNTEERS", AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, AMERICAN PSYCHIATRY PRESS, WASHINGTON, DC, US, vol. 4, no. 9, 21 September 2001 (2001-09-21), pages 429 - 438, XP001079969, ISSN: 1064-7481
BELL C., NUTT D.: "Paroxetine and its uses in psychiatry", HOSPITAL MEDICINE, vol. 60, no. 5, 1999, London, England, pages 353 - 356, XP001094785
JOHNSTON L C ET AL: "THE NOVEL DOPAMINE D2 RECEPTOR PARTIAL AGONIST, SLV-308, REVERSES MOTOR DISABILITY IN MPTP-LESIONED COMMON MARMOSETS (CALLITHRIXJACCHUS)", BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, vol. SUPPL, no. 133, May 2001 (2001-05-01), pages U - 70,AN134P, XP001061442, ISSN: 0007-1188
OLBRICH R ET AL: "AN EVALUATION OF THE PARTIAL DOPAMINE AGONIST TERGURIDE REGARDING POSITIVE SYMPTOMS REDUCTION IN SCHIZOPHRENICS", JOURNAL OF NEURAL TRANSMISSION, SPRINGER VERLAG, VIENNA, AT, vol. 3, no. 84, 1991, pages 233 - 236, XP001061450, ISSN: 0300-9564
LATHI A.C. ET AL: "Antipsychotic properties of the partial dopamine agonist (-)-3-(3-hydroxyphenyl)-N-N-propylpiperidine (Preclamol) in schizophrenia", BIOLOGICAL PSYCHIATRY, vol. 43, no. 1, 1998, pages 2 - 11, XP001079970
FURLAN P M ET AL: "COGNITIVE AND PSYCHOMOTOR EFFECTS OF PAROXETINE AND SERTRALINE ON HEALTHY ELDERLY VOLUNTEERS", AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, AMERICAN PSYCHIATRY PRESS, WASHINGTON, DC, US, vol. 4, no. 9, 21 September 2001 (2001-09-21), pages 429 - 438, XP001079969, ISSN: 1064-7481
BELL C., NUTT D.: "Paroxetine and its uses in psychiatry", HOSPITAL MEDICINE, vol. 60, no. 5, 1999, London, England, pages 353 - 356, XP001094785
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