Title:
PARTIAL FRAGMENT OF REIC/Dkk-3 GENE AND THERAPEUTIC AGENT FOR CANCER CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2008/050898
Kind Code:
A1
Abstract:
It is intended to provide a cancer cell apoptosis inducer containing a REIC/Dkk-3 gene fragment and a therapeutic agent for cancer containing the apoptosis inducer. The following (a) or (b) polynucleotide, which is a fragment of a polynucleotide encoding REIC/Dkk-3 protein and encodes a polypeptide having an apoptosis activity: (a) a polynucleotide encoding a polypeptide which consists of an amino acid sequence starting from an amino acid at position 1 and terminating at an amino acid at any position between position 39 and position 78 in the amino acid sequence of REIC/Dkk-3 protein represented by SEQ ID NO: 2; and (b) a polynucleotide encoding a polypeptide which consists of an amino acid sequence in which one or several amino acids have been substituted, deleted or added in an amino acid sequence starting from an amino acid at position 1 and terminating at an amino acid at any position between position 39 and position 78 in the amino acid sequence of REIC/Dkk-3 protein represented by SEQ ID NO: 2, and has an apoptosis activity.
Inventors:
KUMON HIROMI (JP)
HUH NAM-HO (JP)
SAKAGUCHI MASAKIYO (JP)
NASU YASUTOMO (JP)
ABARZUA CABEZAS FERNANDO GUILL (JP)
HUH NAM-HO (JP)
SAKAGUCHI MASAKIYO (JP)
NASU YASUTOMO (JP)
ABARZUA CABEZAS FERNANDO GUILL (JP)
Application Number:
PCT/JP2007/071170
Publication Date:
May 02, 2008
Filing Date:
October 24, 2007
Export Citation:
Assignee:
UNIV OKAYAMA NAT UNIV CORP (JP)
KUMON HIROMI (JP)
HUH NAM-HO (JP)
SAKAGUCHI MASAKIYO (JP)
NASU YASUTOMO (JP)
ABARZUA CABEZAS FERNANDO GUILL (JP)
KUMON HIROMI (JP)
HUH NAM-HO (JP)
SAKAGUCHI MASAKIYO (JP)
NASU YASUTOMO (JP)
ABARZUA CABEZAS FERNANDO GUILL (JP)
International Classes:
C12N15/09; A61K31/711; A61K38/00; A61K48/00; A61P35/00; A61P43/00; C07K4/12; C07K14/47
Domestic Patent References:
| WO2006098074A1 | 2006-09-21 | |||
| WO2000018426A1 | 2000-04-06 | |||
| WO2001038523A1 | 2001-05-31 | |||
| WO2006098074A1 | 2006-09-21 |
Foreign References:
| JP2006121915A | 2006-05-18 | |||
| JP3813872B2 | 2006-08-23 | |||
| JP2006289040A | 2006-10-26 |
Other References:
HSIEH S.Y. ET AL.: "Dickkopf-3/REIC functions as a suppressor gene of tumor growth", ONCOGENE, vol. 23, 2004, pages 9183 - 9189, XP002998787
ABARZUA F. ET AL.: "Adenovirus-Mediated Overexpression of REIC/Dkk-3 Selectively Induces Apoptosis in Human Prostate Cancer Cells through Activation of c-Jun-NH2-Kinase", CANCER RESEARCH, vol. 65, no. 21, 1 November 2005 (2005-11-01), pages 9617 - 9622, XP002998788
VOGELSTEIN, B. ET AL., TRENDS GENET, vol. 9, 1993, pages 138 - 41
CHEN, P. L. ET AL., SCIENCE, vol. 250, 1990, pages 1576 - 80
FUJIWARA, T. ET AL., J. NATL. CANCER INST., vol. 86, 1994, pages 1458 - 62
NIELSEN, L. L. ET AL., CANCER GENE THER., vol. 4, 1997, pages 129 - 38
FISHER, P. B. ET AL., CANCER BIOL. THER., vol. 2, 2003, pages 23 - 37
TSUJI, T. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 268, 2000, pages 20 - 4
TSUJI, T. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 289, 2001, pages 257 - 63
NOZAKI, I. ET AL., INT. J. ONCOL., vol. 19, 2001, pages 117 - 21
KUROSE, K. ET AL., J. UROL., vol. 171, 2004, pages 1314 - 8
BAFICO, A. ET AL., NAT. CELL BIOL., vol. 3, 2001, pages 683 - 6
HOANG, B. H. ET AL., CANCER RES., vol. 64, 2004, pages 2734 - 9
MOON, R. T. ET AL., SCIENCE, vol. 296, 2002, pages 1644 - 6
D. THOMAS RUTKOWSKI ET AL., TRENDS IN CELL BIOLOGY, vol. 14, no. 1, January 2004 (2004-01-01), pages 20 - 28
MORI K., TRAFFIC, vol. 4, 2003, pages 519 - 528
"Bessatsu Jikken-Igaku, Idenshi-Chiryo-No-Kisogijutsu", 1996, YODOSHA CO., LTD.
"enshi donyu & hatsugen kaiseki jikken-hou", YODOSHA, CO., LTD., article "Bessatsu Jikken Igaku"
"N.T.S.", 1999, JAPAN SOCIETY OF GENE THERAPY, article "Idenshi chiryo kaihatsu kenkyu handbook (the Handbook for research and development of gene therapy"
MIYAKE, S. ET AL., PROC. NATL. ACAD. SCI., U.S.A., vol. 93, 1996, pages 1320
LIEBER, A. ET AL., J. VIROL., vol. 70, 1996, pages 8944
MIZUGUCHI, H.; KAY, M. A., HUM. GENE THER., vol. 10, 1999, pages 2013
STEINWAERDER, D. S. ET AL., J. VIROL., vol. 73, 1999, pages 9303
RECCHIA, A. ET AL., PROC. NATL. ACAD. SCI., U.S.A., vol. 96, 1999, pages 2615
MIZUGUCHI, H.; HAYAKAWA, T., NIPPON RINSHO, vol. 7, 2000, pages 1544
GENE, vol. 108, 1991, pages 193 - 200
NIKKEI SCIENCE, April 1994 (1994-04-01), pages 20 - 45
GEKKAN YAKUJI, vol. 36, no. 1, 1994, pages 23 - 48
JIKKEN IGAKU ZOUKAN, vol. 12, 1994, pages 15
"N. T. S.", 1999, JAPAN SOCIETY OF GENE THERAPY, article "Idenshi chiryo kaihatsu kenkyu handbook"
See also references of EP 2090654A4
ABARZUA F. ET AL.: "Adenovirus-Mediated Overexpression of REIC/Dkk-3 Selectively Induces Apoptosis in Human Prostate Cancer Cells through Activation of c-Jun-NH2-Kinase", CANCER RESEARCH, vol. 65, no. 21, 1 November 2005 (2005-11-01), pages 9617 - 9622, XP002998788
VOGELSTEIN, B. ET AL., TRENDS GENET, vol. 9, 1993, pages 138 - 41
CHEN, P. L. ET AL., SCIENCE, vol. 250, 1990, pages 1576 - 80
FUJIWARA, T. ET AL., J. NATL. CANCER INST., vol. 86, 1994, pages 1458 - 62
NIELSEN, L. L. ET AL., CANCER GENE THER., vol. 4, 1997, pages 129 - 38
FISHER, P. B. ET AL., CANCER BIOL. THER., vol. 2, 2003, pages 23 - 37
TSUJI, T. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 268, 2000, pages 20 - 4
TSUJI, T. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 289, 2001, pages 257 - 63
NOZAKI, I. ET AL., INT. J. ONCOL., vol. 19, 2001, pages 117 - 21
KUROSE, K. ET AL., J. UROL., vol. 171, 2004, pages 1314 - 8
BAFICO, A. ET AL., NAT. CELL BIOL., vol. 3, 2001, pages 683 - 6
HOANG, B. H. ET AL., CANCER RES., vol. 64, 2004, pages 2734 - 9
MOON, R. T. ET AL., SCIENCE, vol. 296, 2002, pages 1644 - 6
D. THOMAS RUTKOWSKI ET AL., TRENDS IN CELL BIOLOGY, vol. 14, no. 1, January 2004 (2004-01-01), pages 20 - 28
MORI K., TRAFFIC, vol. 4, 2003, pages 519 - 528
"Bessatsu Jikken-Igaku, Idenshi-Chiryo-No-Kisogijutsu", 1996, YODOSHA CO., LTD.
"enshi donyu & hatsugen kaiseki jikken-hou", YODOSHA, CO., LTD., article "Bessatsu Jikken Igaku"
"N.T.S.", 1999, JAPAN SOCIETY OF GENE THERAPY, article "Idenshi chiryo kaihatsu kenkyu handbook (the Handbook for research and development of gene therapy"
MIYAKE, S. ET AL., PROC. NATL. ACAD. SCI., U.S.A., vol. 93, 1996, pages 1320
LIEBER, A. ET AL., J. VIROL., vol. 70, 1996, pages 8944
MIZUGUCHI, H.; KAY, M. A., HUM. GENE THER., vol. 10, 1999, pages 2013
STEINWAERDER, D. S. ET AL., J. VIROL., vol. 73, 1999, pages 9303
RECCHIA, A. ET AL., PROC. NATL. ACAD. SCI., U.S.A., vol. 96, 1999, pages 2615
MIZUGUCHI, H.; HAYAKAWA, T., NIPPON RINSHO, vol. 7, 2000, pages 1544
GENE, vol. 108, 1991, pages 193 - 200
NIKKEI SCIENCE, April 1994 (1994-04-01), pages 20 - 45
GEKKAN YAKUJI, vol. 36, no. 1, 1994, pages 23 - 48
JIKKEN IGAKU ZOUKAN, vol. 12, 1994, pages 15
"N. T. S.", 1999, JAPAN SOCIETY OF GENE THERAPY, article "Idenshi chiryo kaihatsu kenkyu handbook"
See also references of EP 2090654A4
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (3-20 Toranomon 4-chom, Minato-ku Tokyo, JP)
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