Title:
PARTIAL REGION POLYPEPTIDE OF REIC/DKK-3 PROTEIN
Document Type and Number:
WIPO Patent Application WO/2012/002582
Kind Code:
A1
Abstract:
Disclosed are: a polypeptide which can strongly induce or activate a dendric-cell-like cell and can treat or prevent cancer through an immunotherapy using the polypeptide; and DNA which encodes the polypeptide. Specifically disclosed is a polypeptide which comprises a partial region of REIC/Dkk-3 protein, and which is selected from: (a) a polypeptide which comprises a partial region of REIC/Dkk-3 protein, and which comprises an amino acid sequence that is selected from the group consisting of the amino acid sequences represented by SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7 and SEQ ID NO:9 and an amino acid sequence for a polypeptide that contains a partial region lying between Gly at position-205 to Phe at position-288 in the amino acid sequence represented by SEQ ID NO:2 and that comprises a fragment of a partial region lying between Ser at position-135 to Ile at position-350 in the amino acid sequence represented by SEQ ID NO:2; and (b) a polypeptide which is a polypeptide protein comprising an amino acid sequence produced by substituting, deleting or adding one or several amino acid residues in an amino acid sequence that is selected from the group consisting of the amino acid sequences represented by SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7 and SEQ ID NO:9 and an amino acid sequence for a polypeptide that contains a partial region lying between Gly at position-205 to Phe at position-288 in the amino acid sequence represented by SEQ ID NO:2 and that comprises a fragment of a partial region lying between Ser at position-135 to Ile at position-350 in the amino acid sequence represented by SEQ ID NO:2, and which has an activity of inducing the differentiation of a monocyte into a dendric-cell-like cell.
Inventors:
KUMON HIROMI (JP)
WATANABE MASAMI (JP)
FUTAMI JUNICHIRO (JP)
FUJII YASUYUKI (JP)
UEKI HIDEO (JP)
OCHIAI KAZUHIKO (JP)
WATANABE MASAMI (JP)
FUTAMI JUNICHIRO (JP)
FUJII YASUYUKI (JP)
UEKI HIDEO (JP)
OCHIAI KAZUHIKO (JP)
Application Number:
PCT/JP2011/065644
Publication Date:
January 05, 2012
Filing Date:
July 01, 2011
Export Citation:
Assignee:
UNIV OKAYAMA NAT UNIV CORP (JP)
MOMOTARO GENE INC (JP)
KUMON HIROMI (JP)
WATANABE MASAMI (JP)
FUTAMI JUNICHIRO (JP)
FUJII YASUYUKI (JP)
UEKI HIDEO (JP)
OCHIAI KAZUHIKO (JP)
MOMOTARO GENE INC (JP)
KUMON HIROMI (JP)
WATANABE MASAMI (JP)
FUTAMI JUNICHIRO (JP)
FUJII YASUYUKI (JP)
UEKI HIDEO (JP)
OCHIAI KAZUHIKO (JP)
International Classes:
C12N15/09; A61K38/00; A61P35/00; A61P37/04; A61P43/00; C07K14/47; C12N5/0786
Domestic Patent References:
| WO2009119874A1 | 2009-10-01 | |||
| WO2000052047A2 | 2000-09-08 | |||
| WO2001038523A1 | 2001-05-31 | |||
| WO2009119874A1 | 2009-10-01 |
Foreign References:
| JP2010150935A | 2010-07-08 | |||
| JP2011014319A | 2011-01-20 |
Other References:
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KRUPNIK, VE. ET AL.: "Functional and structural diversity of the human Dickkopf gene family.", GENE, vol. 238, no. 2, 1999, pages 301 - 313, XP002140768
TSUJI, T. ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 268, 2000, pages 20 - 4
TSUJI, T. ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 289, 2001, pages 257 - 63
NOZAKI, 1. ET AL., INT J ONCOL, vol. 19, 2001, pages 117 - 21
KUROSE, K. ET AL., J UROL, vol. 171, 2004, pages 1314 - 8
BAFICO, A. ET AL., NAT CELL BIOL, vol. 3, 2001, pages 683 - 6
HOANG, B.H. ET AL., CANCER RES, vol. 64, 2004, pages 2734 - 9
MOON, R.T. ET AL., SCIENCE, vol. 296, 2002, pages 1644 - 6
PARMIANI, G. ET AL., ANNALS OF ONCOLOGY, vol. 18, 2007, pages 226 - 32
BESSATSU JIKKEN-IGAKU: "Idenshi-Chiryo-No-Kisogijutsu", 1996, YODOSHA CO., LTD.
"Idenshi donyu & hatsugen kaiseki jikken-hou", 1997, YODOSHA, CO., LTD., article "Bessatsu Jikken Igaku"
"Idenshi chiryo kaihatsu kenkyu handbook", 1999, JAPAN SOCIETY OF GENE THERAPY
MIYAKE, S. ET AL., PROC. NATL. ACAD. SCI., U.S.A., vol. 93, 1996, pages 1320
LIEBER, A., J. VIROL., vol. 70, 1996, pages 8944
MIZUGUCHI, H.; KAY, M. A., HUM. GENE THER., vol. 10, 1999, pages 2013
STEINWAERDER, D. S. ET AL., J. VIROL., vol. 73, 1999, pages 9303
RECCHIA, A. ET AL., PROC. NATL. ACAD. SCI., U.S.A., vol. 96, 1999, pages 2615
MIZUGUCHI, H.; HAYAKAWA, T., NIPPON RINSHO, vol. 7, 2000, pages 1544
GENE, vol. 108, 1991, pages 193 - 200
NIKKEI SCIENCE, April 1994 (1994-04-01), pages 20 - 45
GEKKAN YAKUJI, vol. 36, no. 1, 1994, pages 23 - 48
JIKKEN IGAKU ZOUKAN, vol. 12, no. 15, 1994
"Idenshi chiryo kaihatsu kenkyu", 1999, JAPAN SOCIETY OF GENE THERAPY
KRUPNIK, VE. ET AL.: "Functional and structural diversity of the human Dickkopf gene family.", GENE, vol. 238, no. 2, 1999, pages 301 - 313, XP002140768
TSUJI, T. ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 268, 2000, pages 20 - 4
TSUJI, T. ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 289, 2001, pages 257 - 63
NOZAKI, 1. ET AL., INT J ONCOL, vol. 19, 2001, pages 117 - 21
KUROSE, K. ET AL., J UROL, vol. 171, 2004, pages 1314 - 8
BAFICO, A. ET AL., NAT CELL BIOL, vol. 3, 2001, pages 683 - 6
HOANG, B.H. ET AL., CANCER RES, vol. 64, 2004, pages 2734 - 9
MOON, R.T. ET AL., SCIENCE, vol. 296, 2002, pages 1644 - 6
PARMIANI, G. ET AL., ANNALS OF ONCOLOGY, vol. 18, 2007, pages 226 - 32
BESSATSU JIKKEN-IGAKU: "Idenshi-Chiryo-No-Kisogijutsu", 1996, YODOSHA CO., LTD.
"Idenshi donyu & hatsugen kaiseki jikken-hou", 1997, YODOSHA, CO., LTD., article "Bessatsu Jikken Igaku"
"Idenshi chiryo kaihatsu kenkyu handbook", 1999, JAPAN SOCIETY OF GENE THERAPY
MIYAKE, S. ET AL., PROC. NATL. ACAD. SCI., U.S.A., vol. 93, 1996, pages 1320
LIEBER, A., J. VIROL., vol. 70, 1996, pages 8944
MIZUGUCHI, H.; KAY, M. A., HUM. GENE THER., vol. 10, 1999, pages 2013
STEINWAERDER, D. S. ET AL., J. VIROL., vol. 73, 1999, pages 9303
RECCHIA, A. ET AL., PROC. NATL. ACAD. SCI., U.S.A., vol. 96, 1999, pages 2615
MIZUGUCHI, H.; HAYAKAWA, T., NIPPON RINSHO, vol. 7, 2000, pages 1544
GENE, vol. 108, 1991, pages 193 - 200
NIKKEI SCIENCE, April 1994 (1994-04-01), pages 20 - 45
GEKKAN YAKUJI, vol. 36, no. 1, 1994, pages 23 - 48
JIKKEN IGAKU ZOUKAN, vol. 12, no. 15, 1994
"Idenshi chiryo kaihatsu kenkyu", 1999, JAPAN SOCIETY OF GENE THERAPY
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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