Title:
PARTICLES FOR INHALATION HAVING RAPID RELEASE PROPERTIES
Document Type and Number:
WIPO Patent Application WO2003000202
Kind Code:
A3
Abstract:
The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Improved formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent of any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.
Inventors:
SCHMITKE JENNIFER L
CHEN DONGHAO
BATYCKY RICHARD P
EDWARDS DAVID A
HRKACH JEFFREY S
CHEN DONGHAO
BATYCKY RICHARD P
EDWARDS DAVID A
HRKACH JEFFREY S
Application Number:
PCT/US2002/020280
Publication Date:
August 14, 2003
Filing Date:
June 24, 2002
Export Citation:
Assignee:
ADVANCED INHALATION RES INC (US)
International Classes:
A61K9/00; A61K9/12; A61K9/127; A61K9/16; A61K9/72; A61K9/14; A61K31/137; A61K31/195; A61K38/28; A61K38/30; A61K47/02; A61K47/12; A61K47/16; A61K47/18; A61K47/24; A61K47/48; A61L9/04; A61P3/10; A61P43/00; (IPC1-7): A61K9/12; A61K9/127; A61K9/14; A61K9/72; A61K31/195
Domestic Patent References:
| WO1995000127A1 | 1995-01-05 |
Foreign References:
| US5997848A | 1999-12-07 | |||
| US4673567A | 1987-06-16 |
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