Title:
PD-1, A RECEPTOR FOR B7-4, AND USES THEREFOR
Document Type and Number:
WIPO Patent Application WO2001014557
Kind Code:
B1
Abstract:
The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in order to modulate a costimulatory or an inhibitory signal in an immune cell resulting in modulation of the immune response.
Inventors:
WOOD CLIVE
FREEMAN GORDON J
FREEMAN GORDON J
Application Number:
PCT/US2000/023347
Publication Date:
April 19, 2001
Filing Date:
August 23, 2000
Export Citation:
Assignee:
DANA FARBER CANCER INST INC (US)
GENETICS INST (US)
GENETICS INST (US)
International Classes:
G01N33/50; A61K38/00; A61K39/00; A61K39/395; A61K45/00; A61K45/06; A61P1/16; A61P3/10; A61P9/00; A61P9/10; A61P15/06; A61P19/02; A61P21/04; A61P25/00; A61P25/28; A61P29/00; A61P31/06; A61P31/12; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P33/06; A61P33/12; A61P35/00; A61P37/02; A61P37/04; A61P37/06; A61P37/08; A61P41/00; C07K14/705; C07K16/28; C12N15/09; C12N15/12; C12Q1/02; G01N33/15; G01N33/566; (IPC1-7): C12N15/12; C07K14/705; A61K38/17; A61K39/395; G01N33/50; C07K16/28
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