Title:
PD-L1 ANTIBODY, ANTIGEN-BINDING FRAGMENT THEREOF, AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/137397
Kind Code:
A1
Abstract:
A novel PD-L1 antibody, an antigen-binding fragment thereof, and a pharmaceutical use thereof. A humanized antibody comprising a CDR of the PD-L1 antibody, a pharmaceutical composition comprising the PD-L1 antibody and the antigen-binding fragment thereof, and a use of the PD-L1 antibody as a drug. A use of a humanized PD-L1 antibody in preparing a drug for treating diseases or disorders associated with PD-L1.
Inventors:
GU XIAOLING (CN)
JIANG JIAHUA (CN)
ZHANG LEI (CN)
HU QIYUE (CN)
GU JINMING (CN)
TAO WEIKANG (CN)
JIANG JIAHUA (CN)
ZHANG LEI (CN)
HU QIYUE (CN)
GU JINMING (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2019/070982
Publication Date:
July 18, 2019
Filing Date:
January 09, 2019
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N15/13
Domestic Patent References:
| WO2017084495A1 | 2017-05-26 | |||
| WO2017196867A1 | 2017-11-16 | |||
| WO2014151006A2 | 2014-09-25 | |||
| WO2001039722A2 | 2001-06-07 | |||
| WO2013173223A1 | 2013-11-21 | |||
| WO2014195852A1 | 2014-12-11 | |||
| WO2013181634A2 | 2013-12-05 | |||
| WO2015048520A1 | 2015-04-02 | |||
| WO2015036511A1 | 2015-03-19 | |||
| WO2014100079A1 | 2014-06-26 | |||
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| WO2014022758A1 | 2014-02-06 | |||
| WO2010089411A2 | 2010-08-12 | |||
| WO2017084495A1 | 2017-05-26 |
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| CN106243225A | 2016-12-21 | |||
| CN106699891A | 2017-05-24 | |||
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Other References:
ZHAN, M.M.: "From monoclonal antibodies to small molecules: the develo- pment of inhibitors targeting the PD-1/PD-L1 pathway", DRUG DISCOVERY TODAY, vol. 21, no. 6, 16 April 2016 (2016-04-16), pages 1027 - 1036, XP029565582
HAMANISHI, J.: "Safety and Antitumor Activity of Anti - PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer", JOURNAL OF CLINICAL ONCOLOGY, vol. 33, no. 34, 1 December 2015 (2015-12-01), pages 4015 - 4022, XP055625077
J. BIOL. CHEM, vol. 243, 1968, pages 3558
KABAT E.A. ET AL.: "Sequences of proteins of immunological interest", 1991, NIH
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI USA, vol. 85, 1988, pages 5879 - 5883
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
ALFTHAN ET AL., PROTEIN ENG., vol. 8, 1995, pages 725 - 731
CHOI ET AL., EUR.J.IMMUNO, vol. 1.31, 2001, pages 94 - 106
HU ET AL., CANCER RES., vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV ET AL., J. MOL. BIOL., vol. 293, 1999, pages 41 - 56
ROOVERS ET AL., CANCER IMMUNOL., 2001
PROTEIN ENGINEERING, vol. 7, 1994, pages 697
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
STAHLI ET AL., METHODSIN ENZYMOLOGY, vol. 9, 1983, pages 242 - 253
KIRKLAND ET AL., J. IMMUNOL., vol. 137, 1986, pages 3614 - 3619
MOREL ET AL., MOLEC. IMMUNOL., vol. 25, 1988, pages 7 - 15
CHEUNG ET AL., VIROLOGY, vol. l76, 1990, pages 546 - 552
MOLDENHAUER ET AL., SCAND.J.IMMUNOL., vol. 32, 1990, pages 77 - 82
JOURNAL OF IMMUNOGLOBULINS, 2001, ISBN: 012441351
MULLIS ET AL., COLD SPRING HARBOR SYMP. OUANT. BIOL., vol. 51, 1987, pages 263
"PCR TECHNOLOGY", 1989, STOCKTON PRESS
"WHO Drug Information", vol. 28, 2014, GENETECH, article "Atezolizumab", pages: 488
See also references of EP 3741777A4
HAMANISHI, J.: "Safety and Antitumor Activity of Anti - PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer", JOURNAL OF CLINICAL ONCOLOGY, vol. 33, no. 34, 1 December 2015 (2015-12-01), pages 4015 - 4022, XP055625077
J. BIOL. CHEM, vol. 243, 1968, pages 3558
KABAT E.A. ET AL.: "Sequences of proteins of immunological interest", 1991, NIH
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI USA, vol. 85, 1988, pages 5879 - 5883
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
ALFTHAN ET AL., PROTEIN ENG., vol. 8, 1995, pages 725 - 731
CHOI ET AL., EUR.J.IMMUNO, vol. 1.31, 2001, pages 94 - 106
HU ET AL., CANCER RES., vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV ET AL., J. MOL. BIOL., vol. 293, 1999, pages 41 - 56
ROOVERS ET AL., CANCER IMMUNOL., 2001
PROTEIN ENGINEERING, vol. 7, 1994, pages 697
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
STAHLI ET AL., METHODSIN ENZYMOLOGY, vol. 9, 1983, pages 242 - 253
KIRKLAND ET AL., J. IMMUNOL., vol. 137, 1986, pages 3614 - 3619
MOREL ET AL., MOLEC. IMMUNOL., vol. 25, 1988, pages 7 - 15
CHEUNG ET AL., VIROLOGY, vol. l76, 1990, pages 546 - 552
MOLDENHAUER ET AL., SCAND.J.IMMUNOL., vol. 32, 1990, pages 77 - 82
JOURNAL OF IMMUNOGLOBULINS, 2001, ISBN: 012441351
MULLIS ET AL., COLD SPRING HARBOR SYMP. OUANT. BIOL., vol. 51, 1987, pages 263
"PCR TECHNOLOGY", 1989, STOCKTON PRESS
"WHO Drug Information", vol. 28, 2014, GENETECH, article "Atezolizumab", pages: 488
See also references of EP 3741777A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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