Title:
PEGYLATED TYROSYL-TRNA SYNTHETASE POLYPEPTIDES
Document Type and Number:
WIPO Patent Application WO/2013/022982
Kind Code:
A3
Abstract:
The present invention provides PEGylated tyrosyl-tRNA synthetase (YRS) polypeptides, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The PEGylated YRS polypeptides of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic properties compared to non-PEGylated YRS polypeptides.
Inventors:
WATKINS JEFFRY D (US)
BUECHLER YING JI (US)
WU CHI-FANG (US)
DO MINH-HA (US)
VASSEROT ALAIN P (US)
MENDLEIN JOHN D (US)
BUECHLER YING JI (US)
WU CHI-FANG (US)
DO MINH-HA (US)
VASSEROT ALAIN P (US)
MENDLEIN JOHN D (US)
Application Number:
PCT/US2012/050012
Publication Date:
April 25, 2013
Filing Date:
August 08, 2012
Export Citation:
Assignee:
ATYR PHARMA INC (US)
WATKINS JEFFRY D (US)
BUECHLER YING JI (US)
WU CHI-FANG (US)
DO MINH-HA (US)
VASSEROT ALAIN P (US)
MENDLEIN JOHN D (US)
WATKINS JEFFRY D (US)
BUECHLER YING JI (US)
WU CHI-FANG (US)
DO MINH-HA (US)
VASSEROT ALAIN P (US)
MENDLEIN JOHN D (US)
International Classes:
C12N9/00; A61K38/43; A61P7/00; C12N11/10
Domestic Patent References:
| WO2006034332A2 | 2006-03-30 | |||
| WO2008127900A1 | 2008-10-23 |
Foreign References:
| US20090148887A1 | 2009-06-11 | |||
| US20060246509A1 | 2006-11-02 |
Other References:
DEITERS, ALEXANDER ET AL.: "Site-specific PEGylation of proteins containing unnatural amino acids", BIOORG. MED. CHEM. LETT., vol. 14, no. 23, 6 December 2004 (2004-12-06), pages 5743 - 5745
CHEN, M. ET AL.: "Site-specific incorporation of innatural amino acids into urate oxidase in Escherichia coli.", PROTEIN SCI., vol. 17, no. 10, 2 July 2008 (2008-07-02), pages 1827 - 1833
CHEN, M. ET AL.: "Site-specific incorporation of innatural amino acids into urate oxidase in Escherichia coli.", PROTEIN SCI., vol. 17, no. 10, 2 July 2008 (2008-07-02), pages 1827 - 1833
Attorney, Agent or Firm:
ROGEL, Mark E. et al. (777 - 6th Street NW,Suite 110, Washington District of Columbia, US)
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