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Title:
PENTACYCLIC TRITERPENE COMPOUND AND USE THEREOF IN PREPARATION OF DRUG FOR TREATING ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2015/135474
Kind Code:
A1
Abstract:
Disclosed are a pentacyclic triterpene compound represented by general formula (I) and pharmaceutical compositions containing the compound. Also disclosed is use of the compound in preparation of a PS1/BACE1 interaction inhibitor, and uses thereof in preparation of drugs for treating Alzheimer's disease. Disclosed for the first time is that a pentacyclic triterpene compound represented by general formula (I) can be used as a PS1/BACE1 inhibitor, having activity of inhibiting PS1/BACE1 interaction, and can reduce generation of Aβ and be used in preparation of drugs for treating Alzheimer's disease.

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Inventors:
NAN FAJUN (CN)
XIE XIN (CN)
PEI GANG (CN)
WANG XIAOYIN (CN)
CUI JIN (CN)
ZHAO JIAN (CN)
ZHANG YANGMING (CN)
ZHANG CHENLU (CN)
Application Number:
PCT/CN2015/073987
Publication Date:
September 17, 2015
Filing Date:
March 11, 2015
Export Citation:
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Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
International Classes:
C07J63/00; A61K31/56; A61K31/58; A61P25/28
Domestic Patent References:
WO2006072643A12006-07-13
Foreign References:
CN103622972A2014-03-12
CN103610682A2014-03-05
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
北京金信知识产权代理有限公司 (CN)
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