Title:
PENTACYCLIC TRITERPENOID COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/135449
Kind Code:
A1
Abstract:
The present invention relates to a pentacyclic triterpenoid compound represented by general formula (I) and preparation method thereof, pharmaceutical composition comprising the compound, uses of the compound in preparation of drugs for treating type 2 diebetes, and uses of the compound in treating type 2 diebetes.
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Inventors:
NAN FAJUN (CN)
XIE XIN (CN)
WANG XIAOYIN (CN)
ZHANG SHUYONG (CN)
LI JING (CN)
XIE XIN (CN)
WANG XIAOYIN (CN)
ZHANG SHUYONG (CN)
LI JING (CN)
Application Number:
PCT/CN2015/073855
Publication Date:
September 17, 2015
Filing Date:
March 09, 2015
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
International Classes:
C07J63/00; A61K31/56; A61K31/58; A61P3/10
Foreign References:
| CN1373769A | 2002-10-09 | |||
| US6369109B1 | 2002-04-09 |
Other References:
GENET, C. ET AL.: "Structure-Activity Relationship Study of Betulinic Acid, A Novel and Selective TGR5 Agonist, and Its Synthetic Derivatives: Potential Impact in Diabetes", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 1, 13 November 2009 (2009-11-13), pages 178 - 190, XP055043872, ISSN: 0022-2623
DA SILVA, G.N.S. ET AL.: "Two Series of New Semisynthetic Triterpene Derivatives: Differences in Anti-malarial Activity, Cytotoxicity and Mechanism of Action", MALARIA JOURNAL, vol. 12, no. 89, 9 March 2013 (2013-03-09), pages 1 - 7, XP021146897, ISSN: 1475-2875
HERZ, W. ET AL.: "3-epi-Betulinic Acid, a New Triterpenoid from Picramnia Pentandra", PHYTOCHEMISTRY, vol. 11, no. 10, 31 December 1972 (1972-12-31), pages 3061 - 3063, XP055223561, ISSN: 0031-9422, DOI: doi:10.1016/0031-9422(72)80106-7
ALLISON, J.M. ET AL.: "Dehydrogenation with Mercuric Acetate in the Lupine Series. I. Betulin and Betulinic Acid", JOURNAL OF THE CHEMICAL SOCIETY, 31 December 1961 (1961-12-31), pages 3353 - 3361
DA SILVA, G.N.S. ET AL.: "Two Series of New Semisynthetic Triterpene Derivatives: Differences in Anti-malarial Activity, Cytotoxicity and Mechanism of Action", MALARIA JOURNAL, vol. 12, no. 89, 9 March 2013 (2013-03-09), pages 1 - 7, XP021146897, ISSN: 1475-2875
HERZ, W. ET AL.: "3-epi-Betulinic Acid, a New Triterpenoid from Picramnia Pentandra", PHYTOCHEMISTRY, vol. 11, no. 10, 31 December 1972 (1972-12-31), pages 3061 - 3063, XP055223561, ISSN: 0031-9422, DOI: doi:10.1016/0031-9422(72)80106-7
ALLISON, J.M. ET AL.: "Dehydrogenation with Mercuric Acetate in the Lupine Series. I. Betulin and Betulinic Acid", JOURNAL OF THE CHEMICAL SOCIETY, 31 December 1961 (1961-12-31), pages 3353 - 3361
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
北京金信知识产权代理有限公司 (CN)
北京金信知识产权代理有限公司 (CN)
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