Title:
PENTOPYRANOSYL NUCLEOSIDE, AND PRODUCTION AND USE OF THE SAME
Document Type and Number:
WIPO Patent Application WO1999015539
Kind Code:
A3
Abstract:
The invention relates to a pentopyranosyl nucleoside of formula (I) or formula (II), to the production of said pentopyranosyl nucleoside, and to its use for producing a therapeutic agent, a diagnostic agent and/or an electronic component.
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Inventors:
MICULKA CHRISTIAN (DE)
WINDHAB NORBERT (DE)
BRANDSTETTER TILMANN (DE)
BURDINSKI GERHARD (DE)
WINDHAB NORBERT (DE)
BRANDSTETTER TILMANN (DE)
BURDINSKI GERHARD (DE)
Application Number:
PCT/EP1998/005997
Publication Date:
June 17, 1999
Filing Date:
September 21, 1998
Export Citation:
Assignee:
AVENTIS RES & TECH GMBH & CO (DE)
MICULKA CHRISTIAN (DE)
WINDHAB NORBERT (DE)
BRANDSTETTER TILMANN (DE)
BURDINSKI GERHARD (DE)
MICULKA CHRISTIAN (DE)
WINDHAB NORBERT (DE)
BRANDSTETTER TILMANN (DE)
BURDINSKI GERHARD (DE)
International Classes:
A61K49/00; C07H1/00; C12Q1/68; C07H19/04; C07H19/067; C07H21/00; C07K16/00; G01N33/532; (IPC1-7): C07H21/00; C12Q1/68
Domestic Patent References:
| WO1998025943A1 | 1998-06-18 |
Other References:
S.PITSCH ET AL.: "147. Why Pentose- and Not Hexose-Nucleic Acids ? Pyranosyl-RNA ('p-RNA')", HELVETICA CHIMICA ACTA., vol. 76, no. 6, 1993, BASEL CH, pages 2161 - 2183, XP002094190
S.PITSCH ET AL.: "122. Pyranosyl-RNA ('p-RNA'): Base-Pairing Selectivity and Potential to Replicate.", HELVETICA CHIMICA ACTA., vol. 78, no. 7, 1995, BASEL CH, pages 1621 - 1635, XP002096830
B.DOBOSZEWSKI ET AL.: "Synthesis of 3'-Deoxy-3'-C-Hydroxymethyl-aldopentopyranosyl Nucleosides and their Incorporation into Oligonucleotides. Part II.", TETRAHEDRON, vol. 51, no. 45, 1995, pages 12319 - 12336, XP002096831
J.A.KELLEY ET AL.: "Furanose-pyranose Isomerization of Reduced Pyrimidine and Cyclic Urea Ribosides.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 29, no. 11, November 1986 (1986-11-01), WASHINGTON US, pages 2351 - 2358, XP002097206
CHEMICAL ABSTRACTS, vol. 98, no. 13, 28 March 1983, Columbus, Ohio, US; abstract no. 107682z, H.OGURA: "Glucoside Derivatives." page 636; column 2; XP002097208
M.MELGUIZO ET AL.: "A New One-Step Synthesis of 8-Aminopurines Nucleoside Analogs from 6-(glycosylamino)-5-nitrosopyrimidines.", JOURNAL OF ORGANIC CHEMISTRY., vol. 57, no. 2, 1992, EASTON US, pages 559 - 565, XP002097207
I.SCHLÖNVOGT ET AL.: "188. Pyranosyl-RNA ('p-RNA'): NMR and Molecular Dynamics Study of the DUplex Formed by Self-Pairing of Ribopyranosyl-(C-G-A-A-T-T-C-G)", HELVETICA CHIMICA ACTA., vol. 79, no. 8, 1996, BASEL CH, pages 2316 - 2345, XP002096829
M.BÖHRINGER ET AL.: "110. Warum Pentose- und Nicht Hexose-Nucleinsäuren ? Oligonucleotide aus 2',3'-Dideoxy-B-D-glucopyranosyl-Bausteinen ('Homo-DNS'): Hersellung.", HELVETICA CHIMICA ACTA., vol. 75, no. 5, 13 August 1992 (1992-08-13), BASEL CH, pages 1416 - 1477, XP002096856
M.BOLLI ET AL.: "131. Pyranosyl-RNA : Further Observations on Replication.", HELVETICA CHIMICA ACTA., vol. 80, no. 6, 22 September 1997 (1997-09-22), BASEL CH, pages 1901 - 1951, XP002096832
S.PITSCH ET AL.: "122. Pyranosyl-RNA ('p-RNA'): Base-Pairing Selectivity and Potential to Replicate.", HELVETICA CHIMICA ACTA., vol. 78, no. 7, 1995, BASEL CH, pages 1621 - 1635, XP002096830
B.DOBOSZEWSKI ET AL.: "Synthesis of 3'-Deoxy-3'-C-Hydroxymethyl-aldopentopyranosyl Nucleosides and their Incorporation into Oligonucleotides. Part II.", TETRAHEDRON, vol. 51, no. 45, 1995, pages 12319 - 12336, XP002096831
J.A.KELLEY ET AL.: "Furanose-pyranose Isomerization of Reduced Pyrimidine and Cyclic Urea Ribosides.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 29, no. 11, November 1986 (1986-11-01), WASHINGTON US, pages 2351 - 2358, XP002097206
CHEMICAL ABSTRACTS, vol. 98, no. 13, 28 March 1983, Columbus, Ohio, US; abstract no. 107682z, H.OGURA: "Glucoside Derivatives." page 636; column 2; XP002097208
M.MELGUIZO ET AL.: "A New One-Step Synthesis of 8-Aminopurines Nucleoside Analogs from 6-(glycosylamino)-5-nitrosopyrimidines.", JOURNAL OF ORGANIC CHEMISTRY., vol. 57, no. 2, 1992, EASTON US, pages 559 - 565, XP002097207
I.SCHLÖNVOGT ET AL.: "188. Pyranosyl-RNA ('p-RNA'): NMR and Molecular Dynamics Study of the DUplex Formed by Self-Pairing of Ribopyranosyl-(C-G-A-A-T-T-C-G)", HELVETICA CHIMICA ACTA., vol. 79, no. 8, 1996, BASEL CH, pages 2316 - 2345, XP002096829
M.BÖHRINGER ET AL.: "110. Warum Pentose- und Nicht Hexose-Nucleinsäuren ? Oligonucleotide aus 2',3'-Dideoxy-B-D-glucopyranosyl-Bausteinen ('Homo-DNS'): Hersellung.", HELVETICA CHIMICA ACTA., vol. 75, no. 5, 13 August 1992 (1992-08-13), BASEL CH, pages 1416 - 1477, XP002096856
M.BOLLI ET AL.: "131. Pyranosyl-RNA : Further Observations on Replication.", HELVETICA CHIMICA ACTA., vol. 80, no. 6, 22 September 1997 (1997-09-22), BASEL CH, pages 1901 - 1951, XP002096832
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