Title:
PENTOSAN POLYSULFATE, PHARMACEUTICAL COMPOSITION AND ANTICOAGULANT
Document Type and Number:
WIPO Patent Application WO/2018/159580
Kind Code:
A1
Abstract:
The present invention provides pentosan polysulfate having a weight average molecular weight of 5000 or less and an acetyl group content of 0-2.0 mass% or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof. The pentosan polysulfate or the pharmaceutically acceptable salt thereof, or the pharmaceutically acceptable solvate thereof shows an anti-Xa activity and an anti-Xa/anti-IIa activity ratio which are suitable for practical use, and is useful as pharmaceutical compositions such as anticoagulants.
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Inventors:
ISHIKAWA KOTARO (JP)
KASHIWAMURA TAKURO (JP)
KATO TAKUYA (JP)
KOGA TORU (JP)
ISHIKAWA SUGURU (JP)
KASHIWAMURA TAKURO (JP)
KATO TAKUYA (JP)
KOGA TORU (JP)
ISHIKAWA SUGURU (JP)
Application Number:
PCT/JP2018/007138
Publication Date:
September 07, 2018
Filing Date:
February 27, 2018
Export Citation:
Assignee:
OJI HOLDINGS CORP (JP)
International Classes:
C08B37/14; A61K31/7024; A61L33/08; A61P7/02; C08L5/00; C08L97/02
Domestic Patent References:
| WO2012114349A1 | 2012-08-30 | |||
| WO2012101544A1 | 2012-08-02 | |||
| WO2009087581A1 | 2009-07-16 | |||
| WO2008107906A1 | 2008-09-12 | |||
| WO2018043667A1 | 2018-03-08 | |||
| WO2018043668A1 | 2018-03-08 | |||
| WO2010000013A1 | 2010-01-07 | |||
| WO2014114723A1 | 2014-07-31 |
Foreign References:
| JPS61197601A | 1986-09-01 | |||
| JPS4843100B1 | 1973-12-17 | |||
| US20110251154A1 | 2011-10-13 | |||
| JP2004513185A | 2004-04-30 | |||
| JP6281659B1 | 2018-02-21 | |||
| JP2003183303A | 2003-07-03 |
Other References:
IIZUKA, KEISUKE: "Passage, Technology of wood chemicals", TECHNOLOGY OF WOOD CHEMICALS, 2007, pages 108, XP009515720, ISBN: 978-4-88231-928-3
TETSUO KOSHIJIMA: "Recent Problems of Hemicellulose Chemistry", MATERIAL = JOURNAL OF THE SOCIETY OF MATERIALS SCIENCE, JAPAN, vol. 16, no. 169, 1967, pages 758 - 764, XP009516475, ISSN: 0514-5163
"Wood Chemicals no Gijyutsu (Techniques of Wood Chemicals", 2007, CMC PUBLISHING CO., LTD., pages: 108
See also references of EP 3590971A4
TETSUO KOSHIJIMA: "Recent Problems of Hemicellulose Chemistry", MATERIAL = JOURNAL OF THE SOCIETY OF MATERIALS SCIENCE, JAPAN, vol. 16, no. 169, 1967, pages 758 - 764, XP009516475, ISSN: 0514-5163
"Wood Chemicals no Gijyutsu (Techniques of Wood Chemicals", 2007, CMC PUBLISHING CO., LTD., pages: 108
See also references of EP 3590971A4
Attorney, Agent or Firm:
SIKS & CO. (JP)
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