Title:
PENTOXIFYLLINE SUSTAINED-RELEASE TABLET AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/040173
Kind Code:
A1
Abstract:
A pentoxifylline sustained-release tablet, which comprises the following components: 370-420 parts pentoxifylline, 120-160 parts sustained-release material, 10-16 parts adhesive, 5-10 parts lubricant, and 150-300 parts wetting agent; the sustained-release material is a mixture of carrageenan and xanthan gum or a mixture of carrageenan and konjac gum; the wetting agent is purified water. The pentoxifylline sustained-release tablet is prepared by means of a wet granulation process based on atomization dispersion, using a complex of carrageenan and xanthan or a complex of carrageenan and konjac glucomannan as the sustained-release material and purified water as the wetting agent, thereby improving the problems of unstable sustained-release of pentoxifylline, poor dissolution consistency in an original preparation, and high pentoxifylline viscosity.
Inventors:
SUN LIJIE (CN)
LI LEI (CN)
CHENG YANCHAO (CN)
DONG WEICHANG (CN)
DING LIXIU (CN)
ZUO YUE (CN)
ZHAO WENHE (CN)
LI LEI (CN)
CHENG YANCHAO (CN)
DONG WEICHANG (CN)
DING LIXIU (CN)
ZUO YUE (CN)
ZHAO WENHE (CN)
Application Number:
PCT/CN2022/075613
Publication Date:
March 23, 2023
Filing Date:
February 09, 2022
Export Citation:
Assignee:
SHIJIAZHUANG NO 4 PHARM CO LTD (CN)
International Classes:
A61K9/22; A61K31/522; A61K47/36; A61P7/02; A61P9/10
Foreign References:
| CN113813239A | 2021-12-21 | |||
| CN106138004A | 2016-11-23 | |||
| CN101239050A | 2008-08-13 | |||
| JPH07112934A | 1995-05-02 |
Other References:
ZHANG YU, WANG LING, DU CAI-WEI: "Preparation of sinomenine hydrochlorideÎș-carrageenan/konjac glucomannan matrix tablets and study on its in vitro release mechanism", CHINESE HERBAL MEDICINES, TIANJIN PRESS OF CHINESE HERBAL MEDICINES, CN, vol. 40, no. 11, 30 November 2009 (2009-11-30), CN , pages 1728 - 1732, XP093048332, ISSN: 1674-6384
Attorney, Agent or Firm:
HEBEI GUOWEIZHIYUAN INTELLECTUAL PROPERTY AGENCY CO.,LTD (CN)
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