Title:
PEPTIDE CAPABLE OF INDUCING IMMUNE RESPONSE AGAINST HIV AND AIDS PREVENTIVE OR REMEDY CONTAINING THE PEPTIDE
Document Type and Number:
WIPO Patent Application WO/1995/011255
Kind Code:
A1
Abstract:
A peptide which is a fragment of the whole protein of HIV, the fragment having a sequence of 8 to 11 consecutive amino acid residues, corresponds to an HLA-binding motif, is in fact bound to HLA, and can induce a killer cell that targets HIV-infected cells. It is efficacious as an AIDS preventive or remedy.
Inventors:
TAKIGUCHI MASAFUMI (JP)
MIWA KIYOSHI (JP)
MIWA KIYOSHI (JP)
Application Number:
PCT/JP1994/001756
Publication Date:
April 27, 1995
Filing Date:
October 19, 1994
Export Citation:
Assignee:
AJINOMOTO KK (JP)
TAKIGUCHI MASAFUMI (JP)
MIWA KIYOSHI (JP)
TAKIGUCHI MASAFUMI (JP)
MIWA KIYOSHI (JP)
International Classes:
C07K14/16; A61K38/00; A61K39/00; (IPC1-7): C07K7/06; C07K14/155; A61K38/08
Domestic Patent References:
| WO1993010816A1 | 1993-06-10 |
Foreign References:
| JP4507100A | ||||
| JPH05500517A | 1993-02-04 |
Other References:
J. EXP. MED., Vol. 180, No. 3, (1994), ISABELLE COUILLIN et al., "Impaired Cytotoxic T Lymphocyte Recognition Due to Genetic Variations in the Main Immunogenic Region of the Human Immunodeficiency Virus 1 NEF Protein", page 1129 to 1134.
JOURNAL OF VIROLOGY, Vol. 67, No. 2, (1993), FLORENCE BUSEYNE et al., "Gag-Specific Cytotoxic T Lymphocytes from Human Immunodeficiency Virus Type 1-Infected Individuals: Gag Epitopes are Clustered in Three Regions of the P24gag Protein", page 694 to 702.
See also references of EP 0728764A4
JOURNAL OF VIROLOGY, Vol. 67, No. 2, (1993), FLORENCE BUSEYNE et al., "Gag-Specific Cytotoxic T Lymphocytes from Human Immunodeficiency Virus Type 1-Infected Individuals: Gag Epitopes are Clustered in Three Regions of the P24gag Protein", page 694 to 702.
See also references of EP 0728764A4
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