Title:
PEPTIDE DEFORMYLASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2002028829
Kind Code:
A3
Abstract:
The invention is directed to a novel class of compounds, which inhibits peptide deformylase, pharmaceutical compositions containing compounds that inhibit peptide deformylase, and method of treating various infections.
More Like This:
Inventors:
CHONG LEE
FRECHETTE ROGER
SCOTT CAROLE
TESTER RICHARD
SMITH WHITNEY
CHIBA KATSUMI
SAKAMOTO MASATOSHI
GLUCHOWSKI CHARLES
FRECHETTE ROGER
SCOTT CAROLE
TESTER RICHARD
SMITH WHITNEY
CHIBA KATSUMI
SAKAMOTO MASATOSHI
GLUCHOWSKI CHARLES
Application Number:
PCT/US2001/029926
Publication Date:
December 24, 2003
Filing Date:
September 24, 2001
Export Citation:
Assignee:
QUESTCOR PHARMACEUTICALS INC (US)
International Classes:
A61P31/00; C07C237/22; C07C237/36; C07C259/06; C07C323/60; C07D205/04; C07D207/12; C07D207/14; C07D207/16; C07D207/26; C07D211/22; C07D211/42; C07D217/26; C07D233/54; C07D277/06; C07D277/46; C07D295/185; C07D307/14; C07D307/52; C07D333/68; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D417/12; (IPC1-7): C07D233/54; A01N43/36; A01N43/40; A01N43/42; A01N47/18; A61K31/16; A61K31/40; A61K31/44; A61P31/00; C07C237/36; C07C259/06; C07C323/60; C07D205/04; C07D207/12; C07D207/14; C07D207/16; C07D207/26; C07D211/22; C07D211/42; C07D217/26; C07D277/06; C07D277/46; C07D295/12; C07D295/18; C07D307/14; C07D307/52; C07D333/68; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D417/12; C07K5/06
Domestic Patent References:
WO1999059568A1 | 1999-11-25 | |||
WO2001038561A1 | 2001-05-31 | |||
WO2001044179A1 | 2001-06-21 | |||
WO1995006031A1 | 1995-03-02 | |||
WO1999039704A1 | 1999-08-12 |
Foreign References:
US5712300A | 1998-01-27 | |||
US5840939A | 1998-11-24 |
Other References:
"Antibiotic Actinonin. I to VIII", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY. LETCHWORTH, GB, vol. 9, no. 9, 1975, pages 819 - 860, XP002119637, ISSN: 0300-922X
TAMAKI KAZUHIKO ET AL: "Synthesis and structure-active relationships of gelatinase inhibitors derived from matlystatins", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, JP, vol. 43, no. 11, 1995, pages 1883 - 1893, XP002165817, ISSN: 0009-2363
SATO, TSUTOMU ET AL: "YM-24074, a new peptide antibiotic. II. Structural elucidation.", JOURNAL OF ANTIBIOTICS (1996), 49(8), 811-814, XP002209585
TAMAKI, KAZUHIKO ET AL: "Total synthesis and inhibitory activity against gelatinase B of YL-01869P", J. ANTIBIOT. (1995), 48(1), 87-8, XP002209586
PATENT ABSTRACTS OF JAPAN vol. 018, no. 236 (C - 1196) 6 May 1994 (1994-05-06)
PATENT ABSTRACTS OF JAPAN vol. 015, no. 388 (C - 0872) 2 October 1991 (1991-10-02)
PATENT ABSTRACTS OF JAPAN vol. 015, no. 197 (C - 0833) 21 May 1991 (1991-05-21)
GHOSE A K ET AL: "DETERMINATION OF PHARMACOPHORIC GEOMETRY FOR COLLAGENASE INHIBITORS USING A NOVEL COMPUTATIONAL METHOD AND ITS VERIFICATION USING MOLECULAR DYNAMICS, NMR, AND X-RAY CRYSTALLOGRAPHY", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 117, no. 16, 1995, pages 4671 - 4682, XP002051616, ISSN: 0002-7863
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 05 30 May 1997 (1997-05-30)
INAOKA Y ET AL: "PROPIOXATINS A AND B, NEW ENKEPHALINASE B INHIBITORS III. TOTAL SYNTHESIS OF PROPIOXATIN A", JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. TOKYO, JP, vol. 39, no. 10, October 1986 (1986-10-01), pages 1382 - 1385, XP000978947, ISSN: 0021-8820
INAOKA Y ET AL: "PROPIOXATINS A AND B, NEW ENKEPHALINASE B INHIBITORS. IV. CHARACTERIZATION OF THE ACTIVE SITE OF THE ENZYME USING SYNTHETIC PROPIOXATIN ANALOGUES", JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY, TOKYO, JP, vol. 104, no. 5, November 1988 (1988-11-01), pages 706 - 711, XP000978993, ISSN: 0021-924X
TAMAKI KAZUHIKO ET AL: "Synthesis and structure-active relationships of gelatinase inhibitors derived from matlystatins", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, JP, vol. 43, no. 11, 1995, pages 1883 - 1893, XP002165817, ISSN: 0009-2363
SATO, TSUTOMU ET AL: "YM-24074, a new peptide antibiotic. II. Structural elucidation.", JOURNAL OF ANTIBIOTICS (1996), 49(8), 811-814, XP002209585
TAMAKI, KAZUHIKO ET AL: "Total synthesis and inhibitory activity against gelatinase B of YL-01869P", J. ANTIBIOT. (1995), 48(1), 87-8, XP002209586
PATENT ABSTRACTS OF JAPAN vol. 018, no. 236 (C - 1196) 6 May 1994 (1994-05-06)
PATENT ABSTRACTS OF JAPAN vol. 015, no. 388 (C - 0872) 2 October 1991 (1991-10-02)
PATENT ABSTRACTS OF JAPAN vol. 015, no. 197 (C - 0833) 21 May 1991 (1991-05-21)
GHOSE A K ET AL: "DETERMINATION OF PHARMACOPHORIC GEOMETRY FOR COLLAGENASE INHIBITORS USING A NOVEL COMPUTATIONAL METHOD AND ITS VERIFICATION USING MOLECULAR DYNAMICS, NMR, AND X-RAY CRYSTALLOGRAPHY", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 117, no. 16, 1995, pages 4671 - 4682, XP002051616, ISSN: 0002-7863
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 05 30 May 1997 (1997-05-30)
INAOKA Y ET AL: "PROPIOXATINS A AND B, NEW ENKEPHALINASE B INHIBITORS III. TOTAL SYNTHESIS OF PROPIOXATIN A", JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. TOKYO, JP, vol. 39, no. 10, October 1986 (1986-10-01), pages 1382 - 1385, XP000978947, ISSN: 0021-8820
INAOKA Y ET AL: "PROPIOXATINS A AND B, NEW ENKEPHALINASE B INHIBITORS. IV. CHARACTERIZATION OF THE ACTIVE SITE OF THE ENZYME USING SYNTHETIC PROPIOXATIN ANALOGUES", JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY, TOKYO, JP, vol. 104, no. 5, November 1988 (1988-11-01), pages 706 - 711, XP000978993, ISSN: 0021-924X
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