PEPTIDE DERIVATIVE

Title:

PEPTIDE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2007/145208

Kind Code:

A1

Abstract:

Disclosed is a peptide derivative represented by the general formula: R1N=C(R2)-AA1-AA2-AA3-AA4-Y [wherein R1 represents a hydrogen atom or the like; R2 represents a methyl group or the like; Y represents a methylamino group or the like; AA1 represents a tyrosine residue or the like; AA2 represents a D-arginine residue or the like; AA3 represents a phenylalanine residue or the like; and AA4 represents an N-methyllysine residue or the like] or a salt thereof. The peptide derivative or the salt thereof shows an excellent analgesic effect on various types of pains through subcutaneous or oral administration.

Inventors:

SAKURADA SHINOBU (JP)

Application Number:

PCT/JP2007/061809

Publication Date:

December 21, 2007

Filing Date:

June 12, 2007

Export Citation:

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Assignee:

VEXON INC (JP)
SAKURADA SHINOBU (JP)

International Classes:

C07K5/02; A61K38/00; A61P25/04

Domestic Patent References:

WO1999033864A1	1999-07-08
WO1997035579A1	1997-10-02
WO1995024421A1	1995-09-14
WO1997010261A1	1997-03-20
WO1997010262A1	1997-03-20
WO1999033864A1	1999-07-08

Other References:

See also references of EP 2036918A4
INT. J. PEPTIDE PROTEIN RES., vol. 17, 1981, pages 275
BR. J. PHARMACOL., vol. 95, 1988, pages 15
PEPTIDES, vol. 11, 1990, pages 139
NEUROPHARMACOL., vol. 32, 1993, pages 689
PHARMACOL. BIOCHEM. BEHAV., vol. 24, 1988, pages 27
CHEM. PHARM. BULL., vol. 50, 2002, pages 771 - 780
J. MED. CHEM., vol. 45, 2002, pages 5081 - 5089
CHEM. PHARM. BULL., vol. 51, 2003, pages 759 - 771

Attorney, Agent or Firm:

TAKINO, Hideo et al. (Hiroo SK bldg.36-13, Ebisu 2-chom, Shibuya-ku Tokyo 13, JP)

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