Title:
PEPTIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2010/119864
Kind Code:
A1
Abstract:
Disclosed is a peptide derivative represented by formula: R1N=C(R2)-AA1-AA2-AA3-AA4-Y or a salt thereof, wherein R1 represents a hydrogen molecule or the like; R2 represents a methyl group or the like; Y represents a hydroxyl group; AA1 represents a tyrosine residue or the like; AA2 represents a D-arginine residue or the like; AA3 represents a phenylalanine residue or the like; and AA4 represents a γ-aminobutyric acid residue or the like. By subcutaneously or orally administering the peptide derivative or a salt thereof, an excellent analgesic effect on various kinds of pain is exhibited.
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Inventors:
SAKURADA SHINOBU (JP)
Application Number:
PCT/JP2010/056591
Publication Date:
October 21, 2010
Filing Date:
April 13, 2010
Export Citation:
Assignee:
SAKURADA SHINOBU (JP)
VEXON INC (JP)
VEXON INC (JP)
International Classes:
C07K5/027; A61K38/00; A61P25/04; A61P29/00; C07K5/03
Domestic Patent References:
| WO2007144979A1 | 2007-12-21 | |||
| WO2007145208A1 | 2007-12-21 | |||
| WO1999033864A1 | 1999-07-08 |
Other References:
OGAWA, T. ET AL.: "Synthesis and antinociceptive activity of orally active opioid peptides: improvement of oral bioavailability by esterification.", CHEM. PHARM. BULL., vol. 51, no. 7, 2003, pages 759 - 771
OGAWA, T. ET AL.: "Synthesis and structure- activity relationships of an orally available and long-acting analgesic peptide, N(alpha)- amidino-Tyr-D-Arg-Phe-MebetaAla-OH (ADAMB).", J. MED. CHEM., vol. 45, no. 23, 2002, pages 5081 - 5089
OGAWA, T. ET AL.: "Structure-activity relationships (SAR) of [D-Arg(2)]dermorphin (1-4) analogues, N(alpha)-amidino-Tyr-D-Arg- Phe-X.", CHEM. PHARM. BULL., vol. 50, no. 6, 2002, pages 771 - 780
OGAWA, T. ET AL.: "Synthesis and structure- activity relationships of an orally available and long-acting analgesic peptide, N(alpha)- amidino-Tyr-D-Arg-Phe-MebetaAla-OH (ADAMB).", J. MED. CHEM., vol. 45, no. 23, 2002, pages 5081 - 5089
OGAWA, T. ET AL.: "Structure-activity relationships (SAR) of [D-Arg(2)]dermorphin (1-4) analogues, N(alpha)-amidino-Tyr-D-Arg- Phe-X.", CHEM. PHARM. BULL., vol. 50, no. 6, 2002, pages 771 - 780
Attorney, Agent or Firm:
TAKINO Hideo et al. (JP)
Hideo Takino (JP)
Hideo Takino (JP)
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