Title:
PEPTIDE FOR DIAGNOSING OVARIAN GRANULOSA TUMOR CELLS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/163344
Kind Code:
A1
Abstract:
The present invention relates to a peptide for diagnosing ovarian granulosa tumor cells and a use thereof and, more particularly, to an antibody, a composition and a kit using the peptide, which can be used for diagnosing ovarian granulosa tumor cells by specifically binding to a peptide consisting of an amino acid of SEQ ID NO: 21 and phosphorylation of FOXL2 serine 33 residue. The peptide consisting of the amino acid of SEQ ID NO: 21 and the antibody specifically binding thereto, according to the present invention, can specifically bind to serine, which is the 33rd amino acid of phosphorylated FOXL2, and thus is expected to be effectively used for diagnosing ovarian granulosa tumor cells.
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Inventors:
BAE JEE HYEON (KR)
KIM JAEHONG (KR)
LEE KANG SEOK (KR)
KIM YONG HAK (KR)
OH HOON KYU (KR)
KIM JAEHONG (KR)
LEE KANG SEOK (KR)
KIM YONG HAK (KR)
OH HOON KYU (KR)
Application Number:
PCT/KR2014/002714
Publication Date:
October 09, 2014
Filing Date:
March 31, 2014
Export Citation:
Assignee:
UNIV CHUNG ANG IND (KR)
CATHOLIC UNIV DAEGU INDUSTRY ACADEMIC COOPERATION FOUNDATION (KR)
CATHOLIC UNIV DAEGU INDUSTRY ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
C07K7/06; C07K16/32; G01N33/53
Foreign References:
| US20110195070A1 | 2011-08-11 | |||
| KR20100084706A | 2010-07-27 |
Other References:
GEORGES, A. ET AL.: "SUMOylation of the Forkhead Transcription Factor FOXL2 Promotes Its Stabilization/Activation through Transient Recruitment to PML Bodies", PLOS ONE, vol. 6, 12 October 2011 (2011-10-12), pages E25463
PISARSKA, M. D. ET AL.: "LATS1 phosphorylates forkhead L2 and regulates its transcriptional activity", AM. J. PHYSIOL. ENDOCRINOL. METAB., vol. 299, 20 April 2010 (2010-04-20), pages E101 - E109
KALFA, N. ET AL.: "Extinction of FOXL2 expression in aggressive ovarian granulosa cell tumors in children", FERTIL. STERIL., vol. 87, 30 April 2007 (2007-04-30), pages 896 - 901
PISARSKA, M. D. ET AL.: "LATS1 phosphorylates forkhead L2 and regulates its transcriptional activity", AM. J. PHYSIOL. ENDOCRINOL. METAB., vol. 299, 20 April 2010 (2010-04-20), pages E101 - E109
KALFA, N. ET AL.: "Extinction of FOXL2 expression in aggressive ovarian granulosa cell tumors in children", FERTIL. STERIL., vol. 87, 30 April 2007 (2007-04-30), pages 896 - 901
Attorney, Agent or Firm:
ERUUM PATENT LAW FIRM (KR)
특허법인 이룸 (KR)
특허법인 이룸 (KR)
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