Title:
PEPTIDE-DICER SUBSTRATE RNA CONJUGATES AS DELIVERY VEHICLES FOR SIRNA
Document Type and Number:
WIPO Patent Application WO2007056153
Kind Code:
B1
Abstract:
Provided are compositions comprising a double stranded ribonucleic acid (dsRNA) molecule and a peptide of about 5 to about 40 amino acids, wherein the dsRNA molecule is conjugated to the peptide. The strands of the dsRNA may have lengths from about 25 to about 30 base pairs, which may be the same or different. siRNA may, alternatively, comprise at least three strands (i.e., either at least two sense strands and one antisense strand or at least two antisense strands and one sense strand) wherein the at least two sense strands or the at least two antisense strands are separated by a nick or a gap of at least one nucleotide.
Inventors:
QUAY STEVEN C (US)
JOHNSON PAUL HICKOK (US)
HOUSTON MICHAEL E JR (US)
CUI KUNYUAN (US)
AHMADIAN MOHAMMAD (US)
CHEN LISHAN (US)
CHEN YUCHING (US)
MAYER SASHA J (US)
FAM RENATA (US)
JOHNSON PAUL HICKOK (US)
HOUSTON MICHAEL E JR (US)
CUI KUNYUAN (US)
AHMADIAN MOHAMMAD (US)
CHEN LISHAN (US)
CHEN YUCHING (US)
MAYER SASHA J (US)
FAM RENATA (US)
Application Number:
PCT/US2006/042978
Publication Date:
October 25, 2007
Filing Date:
November 03, 2006
Export Citation:
Assignee:
NASTECH PHARM CO (US)
QUAY STEVEN C (US)
JOHNSON PAUL HICKOK (US)
HOUSTON MICHAEL E JR (US)
CUI KUNYUAN (US)
AHMADIAN MOHAMMAD (US)
CHEN LISHAN (US)
CHEN YUCHING (US)
MAYER SASHA J (US)
FAM RENATA (US)
QUAY STEVEN C (US)
JOHNSON PAUL HICKOK (US)
HOUSTON MICHAEL E JR (US)
CUI KUNYUAN (US)
AHMADIAN MOHAMMAD (US)
CHEN LISHAN (US)
CHEN YUCHING (US)
MAYER SASHA J (US)
FAM RENATA (US)
International Classes:
A61K47/48; C12N15/11; C12N15/113; A61P31/14; A61P31/16; A61P37/00
Download PDF: