Title:
PEPTIDE INHIBITING DIFFERENTIATION OF HEMATOPOIETIC STEM CELLS OR HEMATOPOIETIC PRECURSOR CELLS AND USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2011/040500
Kind Code:
A1
Abstract:
Disclosed is a novel peptide effectively usable in constructing or proliferating in vitro tissue-specific stem cells or tissue-specific precursor cells. The peptide, which is a peptide having an amino acid sequence comprising the amino acid residues represented by SEQ ID NO:1 or an analog of the same, is characterized by having at least one of the following effects: (1) an effect of inhibiting the differentiation of hematopoietic stem cells or hematopoietic precursor cells into myelocytic cells; (2) an effect of promoting the amplification of mesenchymal stem cells; and (3) an effect of inducing hematopoietic stem cells from pluripotent cells.
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Inventors:
SUGIYAMA DAISUKE (JP)
Application Number:
PCT/JP2010/067011
Publication Date:
April 07, 2011
Filing Date:
September 29, 2010
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
SUGIYAMA DAISUKE (JP)
SUGIYAMA DAISUKE (JP)
International Classes:
C07K7/08; C07K7/06; C07K16/18; C12N5/0789
Domestic Patent References:
| WO1997031647A1 | 1997-09-04 |
Foreign References:
| JP2000513329A | 2000-10-10 | |||
| JPH08509358A | 1996-10-08 | |||
| JP2007106760A | 2007-04-26 | |||
| JP2007238473A | 2007-09-20 |
Other References:
SMAS C.M. ET AL.: "Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation.", CELL, vol. 73, no. 4, 1993, pages 725 - 734, XP024245647
See also references of EP 2484689A4
"IUPAC-IUB Communication on Biological Nomenclature", EUR. J. BIOCHEM., vol. 138, 1984, pages 9
BOWIE ET AL., SCIENCE, vol. 247, 1990, pages 1306 - 1310
METHODS IN ENZYMOLOGY, vol. 154, no. 350, 1987, pages 367 - 382
METHODS IN ENZYMOLOGY, vol. 100, 1983, pages 468
NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441
"Idenshi Kenkyuho II", 1986, article "Zoku Seikagaku Jikken Kouza 1", pages: 105
J. AM. CHEM. SOC., vol. 89, 1967, pages 4801
J. AM. CHEM SOC., vol. 91, 1969, pages 3350
SCIENCE, vol. 150, 1968, pages 178
TETRAHEDRON LETT., vol. 22, 1981, pages 1859
TETRAHEDRON LETT., vol. 24, 1983, pages 245
SCHWARTZ, PROC. NATL. ACAD. SCI. USA, vol. 88, 1991, pages 6760
KOLLER, M. R., BIO/TECHNOLOGY, vol. 11, 1993, pages 358
KOLLER, M. R., BLOOD, vol. 82, 1993, pages 378
PALSSON, B. O., BIO/TECHNOLOGY, vol. 11, 1993, pages 368
THIMOTH, A.W., BLOOD, vol. 89, 1997, pages 3624 - 3635
EXP. HEMATOL., vol. 34, 2006, pages 140
CURR OPIN BIOTECHNOL., vol. 19, no. 5, October 2008 (2008-10-01), pages 534 - 540
CELL, vol. 129, no. 7, June 2007 (2007-06-01), pages 1377 - 1388
GEORGE, D., J. EXP. MED., vol. 167, 1988, pages 1939 - 1944
GALLARD, R.E.: "The cytokine facts book", 1994, ACADEMIC PRESS
SCHWARTZ, PROC. NATL. ACAD. SCI. USA., vol. 88, 1991, pages 6760
PALSSON, B. 0., BIO/TECHNOLOGY, vol. 11, 1993, pages 368
"Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
KOHLER G.; MILSTEIN C., NATURE, vol. 256, 1975, pages 495 - 497
SUI X ET AL., PROC NATL ACAD SCI USA, vol. 92, 1995, pages 2859 - 2863
EBIHARA Y ET AL., BLOOD, vol. 90, 1997, pages 4363 - 4368
See also references of EP 2484689A4
"IUPAC-IUB Communication on Biological Nomenclature", EUR. J. BIOCHEM., vol. 138, 1984, pages 9
BOWIE ET AL., SCIENCE, vol. 247, 1990, pages 1306 - 1310
METHODS IN ENZYMOLOGY, vol. 154, no. 350, 1987, pages 367 - 382
METHODS IN ENZYMOLOGY, vol. 100, 1983, pages 468
NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441
"Idenshi Kenkyuho II", 1986, article "Zoku Seikagaku Jikken Kouza 1", pages: 105
J. AM. CHEM. SOC., vol. 89, 1967, pages 4801
J. AM. CHEM SOC., vol. 91, 1969, pages 3350
SCIENCE, vol. 150, 1968, pages 178
TETRAHEDRON LETT., vol. 22, 1981, pages 1859
TETRAHEDRON LETT., vol. 24, 1983, pages 245
SCHWARTZ, PROC. NATL. ACAD. SCI. USA, vol. 88, 1991, pages 6760
KOLLER, M. R., BIO/TECHNOLOGY, vol. 11, 1993, pages 358
KOLLER, M. R., BLOOD, vol. 82, 1993, pages 378
PALSSON, B. O., BIO/TECHNOLOGY, vol. 11, 1993, pages 368
THIMOTH, A.W., BLOOD, vol. 89, 1997, pages 3624 - 3635
EXP. HEMATOL., vol. 34, 2006, pages 140
CURR OPIN BIOTECHNOL., vol. 19, no. 5, October 2008 (2008-10-01), pages 534 - 540
CELL, vol. 129, no. 7, June 2007 (2007-06-01), pages 1377 - 1388
GEORGE, D., J. EXP. MED., vol. 167, 1988, pages 1939 - 1944
GALLARD, R.E.: "The cytokine facts book", 1994, ACADEMIC PRESS
SCHWARTZ, PROC. NATL. ACAD. SCI. USA., vol. 88, 1991, pages 6760
PALSSON, B. 0., BIO/TECHNOLOGY, vol. 11, 1993, pages 368
"Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
KOHLER G.; MILSTEIN C., NATURE, vol. 256, 1975, pages 495 - 497
SUI X ET AL., PROC NATL ACAD SCI USA, vol. 92, 1995, pages 2859 - 2863
EBIHARA Y ET AL., BLOOD, vol. 90, 1997, pages 4363 - 4368
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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