Title:
PEPTIDE INHIBITORS OF NF KAPPA B AND USE THEREOF IN TREATMENT OF COVID-19 AND INFLAMMATORY DISEASES
Document Type and Number:
WIPO Patent Application WO/2022/047225
Kind Code:
A3
Abstract:
Peptides and methods of use thereof, are disclosed for use in treating disorders caused by the novel coronavirus SARS-CoV-2 or resulting from COVID-19 disease, such as systemic inflammation or pneumonia. The peptides modulate the activity of the transcription factor NF ҡB.
Inventors:
BHATNAGAR RAJENDRA SAHAI (US)
Application Number:
PCT/US2021/048049
Publication Date:
April 07, 2022
Filing Date:
August 27, 2021
Export Citation:
Assignee:
BHATNAGAR RAJENDRA SAHAI (US)
International Classes:
A61K38/10; A61K38/08; C07K4/00; C07K4/08; C07K7/06
Domestic Patent References:
| WO2016049580A2 | 2016-03-31 |
Other References:
MERAD MIRIAM; MARTIN JEROME C.: "Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages", NATURE REVIEWS IMMUNOLOGY, NATURE PUBLISHING GROUP UK, LONDON, vol. 20, no. 6, 6 May 2020 (2020-05-06), London, pages 355 - 362, XP037525146, ISSN: 1474-1733, DOI: 10.1038/s41577-020-0331-4
TRAFTON A.: "An experimental peptide could block Covid-19 | MIT News | Massachusetts Institute of Technology", MIT NEWS, 27 March 2020 (2020-03-27), pages 1 - 5, XP055928213, Retrieved from the Internet [retrieved on 20220607]
TRAFTON A.: "An experimental peptide could block Covid-19 | MIT News | Massachusetts Institute of Technology", MIT NEWS, 27 March 2020 (2020-03-27), pages 1 - 5, XP055928213, Retrieved from the Internet
Attorney, Agent or Firm:
CERPA, Robert et al. (US)
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