PHLIP® PEPTIDE-MEDIATED EPITOPE TETHERING AT CELL SURFACES - RHODE ISLAND COUNCIL ON POSTSECONDARY EDUCATION

Title:

PHLIP® PEPTIDE-MEDIATED EPITOPE TETHERING AT CELL SURFACES

Document Type and Number:

WIPO Patent Application WO/2020/160047

Kind Code:

A3

Abstract:

The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIP® construct comprising an antibody recruiting molecule linked to one or more pHLIP® peptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.

Inventors:

RESHETNYAK YANA (US)
ANDREEV OLEG (US)
MOSHNIKOVA ANNA (US)
ENGELMAN DONALD (US)

Application Number:

PCT/US2020/015485

Publication Date:

September 10, 2020

Filing Date:

January 28, 2020

Export Citation:

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Assignee:

RHODE ISLAND COUNCIL ON POSTSECONDARY EDUCATION (US)
UNIV YALE (US)

International Classes:

A61K47/65; A61K49/00; C07K7/06

Foreign References:

US20150051153A1	2015-02-19
US20150190471A1	2015-07-09
US20070160571A1	2007-07-12
US20180057594A1	2018-03-01
US20180369425A1	2018-12-27

Other References:

KRAUSE ET AL.: "Epitopes Expressed in Different Adenovirus Capsid Proteins Induce Different Levels of Epitope-Specific Immunity", J VIROL, vol. 80, no. 11, June 2006 (2006-06-01), pages 5523 - 30, XP002610647, DOI: 10.1128/JVI.02667-05

Attorney, Agent or Firm:

BEATTIE, Ingrid, A. et al. (US)

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