PEPTIDE AND A METHOD OF OBTAINING IT

WIPO Patent Application WO/1996/026955

A1

The invention relates to medicine, specifically, to methods of obtaining biologically active substances with immuno-regulating properties, and can be used in medicine and veterinary science and in experimental biochemistry. The fundamental problem addressed by the invention is that of producing a novel synthetic biologically active peptide with immuno-regulating properties and of the formula: X-Glu-Trp-Y, in which X is H or Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, 'gamma'-aminobutyric acid, 'zeta'-aminocaproic acid; Y is Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, 'gamma'-aminobutyric acid, 'zeta'- aminocaproic acid, -OH, mono- or di-substituted amide (C1-C3). Peptide synthesis takes place in a solution by successive growth of a chain from the C termination of the molecules, using a strategy of maximum blocking of functional groups, starting from amino acid alkyl ether, using the method of activating the ethers and the method of mixed anhydrides using tributyloxicarbonyl amino acid.

DEIGIN VLADISLAV ISAKOVICH (RU)
KOROTKOV ANDREI MARXOVICH (RU)

PCT/RU1996/000046

September 06, 1996

February 28, 1996

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DEIGIN VLADISLAV ISAKOVICH (RU)
KOROTKOV ANDREI MARXOVICH (RU)

A61K38/08; C07K5/02; C07K5/08; C07K5/065; C07K5/072; C07K5/083; C07K5/087; C07K5/09; C07K5/093; C07K5/097; C07K5/10; C07K5/103; C07K5/107; C07K5/113; C07K5/117; A61K38/00; (IPC1-7): C07K5/06; C07K5/08; C07K5/10

SU1277903A3	1986-12-15
CH654841A5	1986-03-14
US4619916A	1986-10-28
EP0148133A2	1985-07-10
GB2109796A	1983-06-08
DE4014230A1	1990-11-08

See also references of EP 0818462A4

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