Title:
PEPTIDE OLIGOMERS FOR USE AS HIV VACCINES
Document Type and Number:
WIPO Patent Application WO2004052933
Kind Code:
B1
Abstract:
Partially occluded and/ or multimeric presentations of peptides mimic the epitopes recognised by antibodies capable of neutralising diverse clinical isolates of the human immunodeficiency virus type 1 (HIV-1). By "partially occluded" is meant a presentation that has a three-dimensional structure (probably a barrel/cylindrical/ helical shape) generated by inter-chain disulphide bridging or other means that has internally, at or near its base, the epitope that is recognised by the neutralising antibody; i.e. a partially occluded presentation is a three-dimensional presentation of one or more neutralising epitopes such that the epitope is located in a pocket or cleft. Such presentations are better at eliciting antibodies that have the neutralising phenotype, and may be used as vaccines or to produce antibodies for the prevention or treatment of HIV-1 infection.
Inventors:
BONEHAM STEVEN PAUL (GB)
BALL JONATHAN KELVIN (GB)
BALL JONATHAN KELVIN (GB)
Application Number:
PCT/GB2003/005436
Publication Date:
May 06, 2005
Filing Date:
December 12, 2003
Export Citation:
Assignee:
UNIV NOTTINGHAM (GB)
BONEHAM STEVEN PAUL (GB)
BALL JONATHAN KELVIN (GB)
BONEHAM STEVEN PAUL (GB)
BALL JONATHAN KELVIN (GB)
International Classes:
C07K14/16; C07K16/10; C12N15/62; A61K39/00; (IPC1-7): C07K14/16; C07K16/10; A61K39/395
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