Title:
PEPTIDE AND PROCESS FOR PREPARING CYCLIC PEPTIDE
Document Type and Number:
WIPO Patent Application WO/1991/007433
Kind Code:
A1
Abstract:
A peptide represented by general formula (I) is cyclized to give a cyclic peptide, preferably a synthetic calcitonin derivative (elcatonin). In the formula, A and B form a peptide represented by the formula Ser-Asn-Leu-Ser-Thr and X is a hydroxyl group, a protective group for a carboxyl group, an amino acid residue or a peptide residue, provided that an amino acid or a peptide is condensed with the side chain carboxyl group of alpha-L-aminosuberic acid. The cyclic peptide is prepared by subjecting the peptide represented by general formula (I) to (1) a cyclization reaction through a chemical condensation, (2) a cyclization reaction in the presence of an alkali metal salt and (3) a reaction comprising a combination of a liquid-phase synthesis with a solid-phase synthesis.
Inventors:
OHSAKI MASUTAKA (JP)
KISHIDA SATOSHI (JP)
INOUE TAKASHI (JP)
KISHIDA SATOSHI (JP)
INOUE TAKASHI (JP)
Application Number:
PCT/JP1990/001440
Publication Date:
May 30, 1991
Filing Date:
November 07, 1990
Export Citation:
Assignee:
DAICEL CHEM (JP)
International Classes:
C07K1/02; C07K1/04; C07K7/02; C07K7/56; C07K14/585; (IPC1-7): C07K1/02; C07K1/04; C07K7/06; C07K7/36
Foreign References:
| JPS549293A | 1979-01-24 | |||
| JPS5359688A | 1978-05-29 | |||
| JPS51128993A | 1976-11-10 |
Other References:
See also references of EP 0452514A4
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