Title:
PEPTIDE SELECTIVELY BINDING TO CANCER CELL-DERIVED EXOSOME, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/035222
Kind Code:
A1
Abstract:
The present invention relates to a peptide selectively binding to a cancer cell-derived exosome, and uses thereof. A peptide of ExoPep (CRKVAKG) has been discovered using a phage display technique to discover a peptide with specific binding ability to an exosome derived from cancer cells. The peptide binds to a cancer cell-derived exosome having a property of moving to a cancer site and a cancer metastasis site, and thus may have the effect of delivering an anticancer drug to the cancer metastasis site.
Inventors:
LEE BYUNG-HEON (KR)
CHAE YOUNGJI (KR)
KHAN FATIMA (KR)
CHAE YOUNGJI (KR)
KHAN FATIMA (KR)
Application Number:
PCT/KR2021/010657
Publication Date:
February 17, 2022
Filing Date:
August 11, 2021
Export Citation:
Assignee:
KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR)
International Classes:
C07K14/00; A61K31/704; A61K38/00; A61K47/42; A61K51/08; C07K7/08; G01N33/574
Foreign References:
| KR20160130949A | 2016-11-15 | |||
| US20120321653A1 | 2012-12-20 | |||
| US20180015182A1 | 2018-01-18 | |||
| KR20190072466A | 2019-06-25 |
Other References:
CARNEY RANDY P., HAZARI SIDHARTHA, ROJALIN TATU, KNUDSON ALISHA, GAO TINGJUAN, TANG YUCHEN, LIU RUIWU, VIITALA TAPANI, YLIPERTTULA: "Targeting Tumor‐Associated Exosomes with Integrin‐Binding Peptides", ADVANCED BIOSYSTEMS, vol. 1, no. 5, 1 May 2017 (2017-05-01), pages 1600038, XP055900253, ISSN: 2366-7478, DOI: 10.1002/adbi.201600038
CREIGHTON: "Proteins; Structures and Molecular Principles", 1983, W. H. FREEMAN AND CO.
"Chemical Approaches to the Synthesis of Peptides and Proteins", 1997, CRC PRESS
"A Practical Approach", 1989, IRL PRESS
WU ET AL., J. BIO. CHEM., vol. 267, 1992, pages 963 - 967
WUWU, J. BIO. CHEM., vol. 263, 1988, pages 14621 - 14624
CREIGHTON: "Proteins; Structures and Molecular Principles", 1983, W. H. FREEMAN AND CO.
"Chemical Approaches to the Synthesis of Peptides and Proteins", 1997, CRC PRESS
"A Practical Approach", 1989, IRL PRESS
WU ET AL., J. BIO. CHEM., vol. 267, 1992, pages 963 - 967
WUWU, J. BIO. CHEM., vol. 263, 1988, pages 14621 - 14624
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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