Title:
PEPTIDE FOR TRANSPORT TO CYTOPLASM
Document Type and Number:
WIPO Patent Application WO/2016/052442
Kind Code:
A1
Abstract:
In order to transport protein encapsulated by endocytosis to cytoplasm with high efficiency, provided is a peptide represented by formula (I): R1-IWLTALKFX1GKHX2AKHX3AKQX4L-R2.(I) (In the formula, X1 is L, E or D. X2 is A, E or D. X3 is L, E, or D. X4 is Q, E, or D. At least one of X1 through X4 is E or D. R1 is a hydrogen atom, acyl group, alkoxycarbonyl group, aralkyloxycarbonyl group or aryloxycarbonyl group. R2 is a hydroxyl group (OH), amino group (NH2), S-R2a, SK-R2a, or SKL-R2a (where R2a is OH or NH2), alkoxy group, aralkyloxy group, or aryloxy group. The amino acid may be either the l-form or the d-form of an amino acid.)
Inventors:
FUTAKI SHIROH (JP)
AKISHIBA MISAO (JP)
KAWAGUCHI YOSHIMASA (JP)
TAKEUCHI TOSHIHIDE (JP)
AKISHIBA MISAO (JP)
KAWAGUCHI YOSHIMASA (JP)
TAKEUCHI TOSHIHIDE (JP)
Application Number:
PCT/JP2015/077395
Publication Date:
April 07, 2016
Filing Date:
September 28, 2015
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C07K14/00; A61K9/127; A61K47/42; C07K14/435
Other References:
AKISHIBA MISAO ET AL.: "Novel Peptide Sequence for Endosome Disruption Derived from Natural Hemolytic Peptide", PEPTIDE SCINECE 2014, 23 April 2015 (2015-04-23), pages 33 - 34, ISBN: 978-4-931541-15-3
HUGHES STEPHEN R. ET AL.: "Cell -Penetrating Recombinant Peptides for Potential Use in Agricultural Pest Control Applications", PHARMACEUTICALS, vol. 5, 2012, pages 1054 - 1063
OHMORI NAOYA ET AL.: "The Enhancing Effect of Anionic alpha-Helical Peptide on Cationic Peptide- Mediating Transfection Systems", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 235, 1997, pages 726 - 729
HUGHES STEPHEN R. ET AL.: "Cell -Penetrating Recombinant Peptides for Potential Use in Agricultural Pest Control Applications", PHARMACEUTICALS, vol. 5, 2012, pages 1054 - 1063
OHMORI NAOYA ET AL.: "The Enhancing Effect of Anionic alpha-Helical Peptide on Cationic Peptide- Mediating Transfection Systems", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 235, 1997, pages 726 - 729
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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