Title:
PEPTIDE VACCINE
Document Type and Number:
WIPO Patent Application WO/2011/090065
Kind Code:
A1
Abstract:
Disclosed is a peptide which has a good immunogenicity and is capable of inducing an enhanced antibody productivity and additional administration of which can enhance the production of the target antibody.
Specifically disclosed is a peptide comprising the amino acid sequence of a cell-binding motif of a cell adhesion molecule, an amino acid sequence (T) containing the amino acid sequence of a T cell epitope having an established immunological memory, an amino acid sequence (B) containing the amino acid sequence(s) of one or more specific B cell epitopes of an antigen, and the amino acid sequence of a linker peptide that is positioned between the aforesaid amino acid sequences (T) and (B) in such a manner as to link these amino acid sequences, characterized in that the amino acid sequence of said linker peptide is GKK, VKK or VVKK. Also disclosed are a medicinal composition which comprises the aforesaid peptide as the active ingredient and use of the same.
Inventors:
KANAZAWA YOSHITO (JP)
MAKINO MITSUHIRO (JP)
MIWA YOSHIKATSU (JP)
YANO AKIRA (JP)
MAKINO MITSUHIRO (JP)
MIWA YOSHIKATSU (JP)
YANO AKIRA (JP)
Application Number:
PCT/JP2011/050848
Publication Date:
July 28, 2011
Filing Date:
January 19, 2011
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
HAYASHIBARA BIOCHEM LAB (JP)
KANAZAWA YOSHITO (JP)
MAKINO MITSUHIRO (JP)
MIWA YOSHIKATSU (JP)
YANO AKIRA (JP)
HAYASHIBARA BIOCHEM LAB (JP)
KANAZAWA YOSHITO (JP)
MAKINO MITSUHIRO (JP)
MIWA YOSHIKATSU (JP)
YANO AKIRA (JP)
International Classes:
C12N15/09; A61K39/00; A61P25/28; C07K14/00; C07K19/00
Domestic Patent References:
| WO2007097251A1 | 2007-08-30 | |||
| WO2004087767A1 | 2004-10-14 |
Other References:
AKIRA YONO: "Saibo Ketsugo Hairetsu o Mochiita Ikyushusei Peptide Seizai no Sekkei", RESEARCH OF NEW MEDICAL DEVICES, vol. 11, 25 March 2006 (2006-03-25), pages 16, XP003017253
ADAMS, M. J. ET AL.: "Overview and analysis of the polyprotein cleavage sites in the family Potyviridae.", MOL. PLANT PATHOL., vol. 6, no. 4, 2005, pages 471 - 487
ADAMS, M. J. ET AL.: "Overview and analysis of the polyprotein cleavage sites in the family Potyviridae.", MOL. PLANT PATHOL., vol. 6, no. 4, 2005, pages 471 - 487
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
Takashi Shoji (JP)
Takashi Shoji (JP)
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Claims: