Title:
PEPTIDES THAT BIND EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
Document Type and Number:
WIPO Patent Application WO/2010/080248
Kind Code:
A3
Abstract:
Methods, compositions and kits for treating proliferative and non-proliferative diseases associated with abnormal protein synthesis. Chimeric peptide constructs are comprised in compositions and kits for use in the treatment of proliferative diseases, such as ovarian cancer, and for inhibiting protein synthesis in a tumor cell compared to a non-tumor cell.
Inventors:
NAORA HONAMI (US)
Application Number:
PCT/US2009/066424
Publication Date:
September 30, 2010
Filing Date:
December 02, 2009
Export Citation:
Assignee:
UNIV TEXAS (US)
NAORA HONAMI (US)
NAORA HONAMI (US)
International Classes:
A61P35/00; C07K19/00
Foreign References:
| US20080206201A1 | 2008-08-28 |
Other References:
PHALGUNI GHOSH ET AL.: "Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein", PROTEIN EXPRESSION AND PURIFICATION, vol. 60, no. 2, 31 March 2008 (2008-03-31), pages 132 - 139
JEREMY R. GRAFF ET AL.: "Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy", CANCER RESEARCH, vol. 68, no. 3, 1 February 2008 (2008-02-01), pages 631 - 634
TERENCE P. HERBERT ET AL.: "Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E", CURRENT BIOLOGY, vol. 10, no. 13, 16 June 2000 (2000-06-16), pages 793 - 796
ALAIN JOLIOT ET AL.: "Transduction peptides: from technology to physiology", NATURE CELL BIOLOGY, vol. 6, no. 3, March 2004 (2004-03-01), pages 189 - 196
VIVIAN H. Y. ET AL.: "Analysis of the regulatory motifs in eukaryotic initiation factor 4E-binding protein 1", FEBS JOURNAL, vol. 275, no. 9, 1 April 2008 (2008-04-01), pages 2185 - 2199
SONG YI KO ET AL.: "Inhibition of Ovarian Cancer Growth by a Tumor-Targeting Peptide That Binds Eukaryotic Translation Initiation Factor 4E", CLINICAL CANCER RESEARCH, vol. 15, no. 13, 19 May 2009 (2009-05-19), pages 4336 - 4347
JEREMY R. GRAFF ET AL.: "Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy", CANCER RESEARCH, vol. 68, no. 3, 1 February 2008 (2008-02-01), pages 631 - 634
TERENCE P. HERBERT ET AL.: "Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E", CURRENT BIOLOGY, vol. 10, no. 13, 16 June 2000 (2000-06-16), pages 793 - 796
ALAIN JOLIOT ET AL.: "Transduction peptides: from technology to physiology", NATURE CELL BIOLOGY, vol. 6, no. 3, March 2004 (2004-03-01), pages 189 - 196
VIVIAN H. Y. ET AL.: "Analysis of the regulatory motifs in eukaryotic initiation factor 4E-binding protein 1", FEBS JOURNAL, vol. 275, no. 9, 1 April 2008 (2008-04-01), pages 2185 - 2199
SONG YI KO ET AL.: "Inhibition of Ovarian Cancer Growth by a Tumor-Targeting Peptide That Binds Eukaryotic Translation Initiation Factor 4E", CLINICAL CANCER RESEARCH, vol. 15, no. 13, 19 May 2009 (2009-05-19), pages 4336 - 4347
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