PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE

Title:

PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE

Document Type and Number:

WIPO Patent Application WO/2011/008992

Kind Code:

A3

Abstract:

Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.

Inventors:

TSIEN ROGER (US)
AGUILERA TODD (US)
OLSON EMILIA (US)
JIANG TAO (US)
NGUYEN QUYEN (US)

Application Number:

PCT/US2010/042184

Publication Date:

June 30, 2011

Filing Date:

July 15, 2010

Export Citation:

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Assignee:

UNIV CALIFORNIA (US)
TSIEN ROGER (US)
AGUILERA TODD (US)
OLSON EMILIA (US)
JIANG TAO (US)
NGUYEN QUYEN (US)

International Classes:

C07K7/06; A61K47/42; A61K49/00; C07K7/08; G01N33/52; G01N33/68

Foreign References:

US20070041904A1	2007-02-22
US20010021763A1	2001-09-13
US20040241096A1	2004-12-02
US20090004118A1	2009-01-01
US20040009122A1	2004-01-15
US5910300A	1999-06-08

Other References: