Title:
PEPTIDOMIMETIC COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/185763
Kind Code:
A1
Abstract:
A peptidomimetic compound, and a preparation method, pharmaceutical composition and use therefor. Specifically, disclosed are a peptidomimetic compound represented by general formula (I), or a racemate, a cis-trans isomer, an enantiomer, a diastereomer or a mixture thereof, or a metabolite thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof. Also disclosed is a use of the compound in inhibiting coronaviruses comprising SARS-CoV-2, SARS-CoV, MERS-CoV, FIPV, as well as others including RNA viruses such as EV71, EV68 and norovirus.
Inventors:
LIU HONG (CN)
HU SHULEI (CN)
LI JIAN (CN)
ZHANG LEIKE (CN)
DAI WENHAO (CN)
XIE XIONG (CN)
JIANG HUALIANG (CN)
CHEN KAIXIAN (CN)
XIAO GENGFU (CN)
HU SHULEI (CN)
LI JIAN (CN)
ZHANG LEIKE (CN)
DAI WENHAO (CN)
XIE XIONG (CN)
JIANG HUALIANG (CN)
CHEN KAIXIAN (CN)
XIAO GENGFU (CN)
Application Number:
PCT/CN2023/084172
Publication Date:
October 05, 2023
Filing Date:
March 27, 2023
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCIENCE (CN)
WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCIENCE (CN)
International Classes:
C07K5/062; A61K31/404; A61K31/4184; A61K38/05; A61P31/14; C07D403/12; C07D405/12; C07K1/02; C07K1/12; C07K5/078; C07K5/083; C07K5/097; C07K5/117
Domestic Patent References:
| WO2021250648A1 | 2021-12-16 | |||
| WO2022020711A1 | 2022-01-27 | |||
| WO2022020242A1 | 2022-01-27 | |||
| WO2021226546A1 | 2021-11-11 | |||
| WO2022021841A1 | 2022-02-03 | |||
| WO2017197377A1 | 2017-11-16 | |||
| WO2018042343A2 | 2018-03-08 |
Foreign References:
| JP2023000996A | 2023-01-04 | |||
| CN102838523A | 2012-12-26 |
Attorney, Agent or Firm:
XU & PARTNERS , LLC. (CN)
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