Title:
PEPTIDOMIMETIC LIGANDS FOR CELLULAR RECEPTORS AND ION CHANNELS
Document Type and Number:
WIPO Patent Application WO2001070684
Kind Code:
A3
Abstract:
One aspect of the present invention relates to novel peptidomimetic compounds. A second aspect of the present invention relates to the use of the novel peptidomimetic compounds as ligands - agonists or antagonists - for various cellular receptors, e.g., G-protein-coupled receptors and opioid receptors, and various cellular ion channels, e.g., sodium and calcium. In certain embodiments, compounds of the present invention preferentially or selectively inhibit sodium or calcium ion channels. In certain embodiments, compounds of the present invention preferentially or selectively agonize or antagonize mu -opioid receptors. In certain embodiments, compounds of the present invention preferentially or selectively inhibit sodium or calcium ion channels and agonize or antagonize mu -opioid receptors.
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Inventors:
PERSONS PAUL E (US)
HOLLAND JOANNE M (US)
HAUSKE JAMES R (US)
HOLLAND JOANNE M (US)
HAUSKE JAMES R (US)
Application Number:
PCT/US2001/006173
Publication Date:
March 07, 2002
Filing Date:
February 27, 2001
Export Citation:
Assignee:
SEPRACOR INC (US)
PERSONS PAUL E (US)
HOLLAND JOANNE M (US)
HAUSKE JAMES R (US)
PERSONS PAUL E (US)
HOLLAND JOANNE M (US)
HAUSKE JAMES R (US)
International Classes:
C07C275/26; C07C275/28; C07C275/30; C07C275/34; C07D207/14; C07D207/16; C07D213/56; C07D217/26; C07D295/185; C07D401/12; (IPC1-7): C07D207/14; C07D401/12; C07D217/26; C07D295/18; C07D207/16; C07D213/56; C07C275/26; C07C275/30; C07C275/34; C07C275/28; A61K31/401; A61K31/47; A61K31/17; A61P29/02
Domestic Patent References:
| WO1999065932A1 | 1999-12-23 | |||
| WO2001010439A1 | 2001-02-15 | |||
| WO1999067206A1 | 1999-12-29 | |||
| WO1996040208A1 | 1996-12-19 | |||
| WO1998049141A1 | 1998-11-05 |
Foreign References:
| US5364850A | 1994-11-15 |
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