Title:
PERCUTANEOUS ABSORPTION AGENT
Document Type and Number:
WIPO Patent Application WO/2023/286120
Kind Code:
A1
Abstract:
In this percutaneous absorption agent, an ionic liquid is finely dispersed in an oil phase, the ionic liquid including a hydrophilic peptide drug, choline, and carboxylate ions obtained by dissociation of hydrogen ions from carboxy groups of a fatty acid. The average particle diameter of the ionic liquid finely dispersed in the oil phase may be 1-100 nm. The centers of particles of the ionic liquid finely dispersed in the oil phase may comprise the hydrophilic peptide drug and one or more selected from the group consisting of choline propionate, choline lactate, and choline formate. The hydrophilic peptide drug may be insulin. The fatty acid may be oleic acid or linoleic acid. The percutaneous absorption agent may further include sorbitan monolaurate in the oil phase.
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Inventors:
GOTO MASAHIRO (JP)
WAKABAYASHI RIE (JP)
WAKABAYASHI RIE (JP)
Application Number:
PCT/JP2021/026117
Publication Date:
January 19, 2023
Filing Date:
July 12, 2021
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
A61K47/12; A61K9/10; A61K38/02; A61K38/28; A61K47/14; A61K47/18
Foreign References:
| CN111588846A | 2020-08-28 |
Other References:
ISLAM MD. RAFIQUL, CHOWDHURY MD. RAIHAN, WAKABAYASHI RIE, KAMIYA NORIHO, MONIRUZZAMAN MUHAMMAD, GOTO MASAHIRO: "Ionic Liquid-In-Oil Microemulsions Prepared with Biocompatible Choline Carboxylic Acids for Improving the Transdermal Delivery of a Sparingly Soluble Drug", PHARMACEUTICS, vol. 12, no. 4, pages 392, XP093025142, DOI: 10.3390/pharmaceutics12040392
TAHARA, YOSHIRO ET AL.: "1P-047 Improvement in biocompatibility of ionic liquids and application to DDS", PREPRINTS OF THE ANNUAL MEETING OF THE JAPANESE SOCIETY FOR BIOMATERIALS, vol. 40, 30 November 2017 (2017-11-30), pages 302, XP009542698
TAHARA YOSHIRO, MORITA KAHO, WAKABAYASHI RIE, KAMIYA NORIHO, GOTO MASAHIRO: "Biocompatible Ionic Liquid Enhances Transdermal Antigen Peptide Delivery and Preventive Vaccination Effect", MOLECULAR PHARMACEUTICS, AMERICAN CHEMICAL SOCIETY, US, vol. 17, no. 10, 5 October 2020 (2020-10-05), US , pages 3845 - 3856, XP055894707, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.0c00598
JORGE LUDMILLA R., HARADA LILIAM K., SILVA ERICA C., CAMPOS WELIDA F., MORELI FERNANDA C., SHIMAMOTO GUSTAVO, PEREIRA JORGE F. B.,: "Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies", FRONTIERS IN PHARMACOLOGY, vol. 11, XP093025146, DOI: 10.3389/fphar.2020.00243
AMRITA BANERJEE, ET AL.: "Transdermal Protein Delivery Using Choline and Geranate (CAGE) Deep Eutectic Solvent", ADVANCED HEALTHCARE MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 6, no. 15, 9 August 2017 (2017-08-09), DE , pages 1601411, XP055611365, ISSN: 2192-2640, DOI: 10.1002/adhm.201601411
TAHARA, YOSHIRO ET AL.: "1P-047 Improvement in biocompatibility of ionic liquids and application to DDS", PREPRINTS OF THE ANNUAL MEETING OF THE JAPANESE SOCIETY FOR BIOMATERIALS, vol. 40, 30 November 2017 (2017-11-30), pages 302, XP009542698
TAHARA YOSHIRO, MORITA KAHO, WAKABAYASHI RIE, KAMIYA NORIHO, GOTO MASAHIRO: "Biocompatible Ionic Liquid Enhances Transdermal Antigen Peptide Delivery and Preventive Vaccination Effect", MOLECULAR PHARMACEUTICS, AMERICAN CHEMICAL SOCIETY, US, vol. 17, no. 10, 5 October 2020 (2020-10-05), US , pages 3845 - 3856, XP055894707, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.0c00598
JORGE LUDMILLA R., HARADA LILIAM K., SILVA ERICA C., CAMPOS WELIDA F., MORELI FERNANDA C., SHIMAMOTO GUSTAVO, PEREIRA JORGE F. B.,: "Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies", FRONTIERS IN PHARMACOLOGY, vol. 11, XP093025146, DOI: 10.3389/fphar.2020.00243
AMRITA BANERJEE, ET AL.: "Transdermal Protein Delivery Using Choline and Geranate (CAGE) Deep Eutectic Solvent", ADVANCED HEALTHCARE MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 6, no. 15, 9 August 2017 (2017-08-09), DE , pages 1601411, XP055611365, ISSN: 2192-2640, DOI: 10.1002/adhm.201601411
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
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