Title:
PERIPHERALLY RESTRICTED GABA POSITIVE ALLOSTERIC MODULATORS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME AND OTHER AILMENTS OF THE PERIPHERAL NERVOUS SYSTEM
Document Type and Number:
WIPO Patent Application WO/2024/030535
Kind Code:
A3
Abstract:
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt thereof, or an N-oxide thereof), which are positive allosteric modulators of one or more GABA-A receptors, e.g., which are peripherally restricted, positive allosteric modulators of one or more GABA-A receptors; e.g., which are positive allosteric modulators of one or more GABA-A receptors and which selectively target the peripheral nervous system and organs of the body, and which do not substantially pass through the blood-brain barrier. Said compounds are useful e.g., for the treatment of systemic diseases of the body, e.g., diseases in which modulation of one or more peripherally restricted GABA-A receptors is beneficial.
Inventors:
BARROW JAMES C (US)
BUCHLER INGRID (US)
HUANG YIFANG (US)
POSLUSNEY MICHAEL (US)
PASRICHA PANKAJ JAY (US)
BUCHLER INGRID (US)
HUANG YIFANG (US)
POSLUSNEY MICHAEL (US)
PASRICHA PANKAJ JAY (US)
Application Number:
PCT/US2023/029383
Publication Date:
April 11, 2024
Filing Date:
August 03, 2023
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
LIEBER INST INC (US)
LIEBER INST INC (US)
International Classes:
A61K31/395; A61K31/40; A61K31/5513; A61K31/33
Attorney, Agent or Firm:
KENDALL, John T. et al. (US)
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