Title:
PERKINSON DISEASE-RELATED GENE GRK5 AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2006/112456
Kind Code:
A1
Abstract:
As a result of a large scale SNP analysis on a group of Perkinson disease patients and a control group of normal persons, it has succeeded in the identification of a gene involved in Perkinson disease (GRK5). It is now found that the increase in the expression of the GRK5 gene induces the enhancement of the phosphorylation of &agr -synuclein, which in turn induces the enhancement of the formation of a soluble &agr -synuclein oligomer, leading to the development of Perkinson disease. It becomes possible to diagnose Perkinson disease and screen a therapeutic agent for Perkinson disease by using the expression of the GRK5 gene.
Inventors:
KATO TAKEO (JP)
ARAWAKA SHIGEKI (JP)
MATSUMINE HIROTO (JP)
ARAWAKA SHIGEKI (JP)
MATSUMINE HIROTO (JP)
Application Number:
PCT/JP2006/308118
Publication Date:
October 26, 2006
Filing Date:
April 18, 2006
Export Citation:
Assignee:
HUBIT GENOMIX INC (JP)
KATO TAKEO (JP)
ARAWAKA SHIGEKI (JP)
MATSUMINE HIROTO (JP)
KATO TAKEO (JP)
ARAWAKA SHIGEKI (JP)
MATSUMINE HIROTO (JP)
International Classes:
C12Q1/68; A61K31/7088; A61K48/00; A61P25/16; C12N15/09; G01N33/15; G01N33/50; G01N33/53
Other References:
PRONIN A.N. ET AL.: "Syncleins are a novel class of substrates for G protein-coupled receptor Kinases", J. BIOL. CHEM., vol. 275, no. 34, 2000, pages 26515 - 26522, XP003003135
KUNAPULI P. ET AL.: "Cloning and expression of GRK5: A member of the G protein-coupled receptor kinase family", PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5588 - 5592, XP002231578
OKOCHI M ET AL.: "Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein", J BIOL CHEM., vol. 275, 2000, pages 390 - 397, XP002909030, DOI: doi:10.1074/jbc.275.1.390
SAITO Y ET AL.: "Accumulation of phosphorylated alpha-synuclein in aging human brain", J. NEUROPATHOL. EXP. NEUROL, vol. 62, 2003, pages 644 - 654
KUNAPULI P. ET AL.: "Cloning and expression of GRK5: A member of the G protein-coupled receptor kinase family", PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5588 - 5592, XP002231578
OKOCHI M ET AL.: "Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein", J BIOL CHEM., vol. 275, 2000, pages 390 - 397, XP002909030, DOI: doi:10.1074/jbc.275.1.390
SAITO Y ET AL.: "Accumulation of phosphorylated alpha-synuclein in aging human brain", J. NEUROPATHOL. EXP. NEUROL, vol. 62, 2003, pages 644 - 654
Attorney, Agent or Firm:
Shimizu, Hatsushi (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki 47, JP)
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