MOUSAVI SANI SEYEDEH AYNAZ (IR)
| EP2689805A1 | 2014-01-29 |
MOGHBEL ABDOLHOSSEIN, FARJZADEH AHMAD, AGHEL NASRIN, AGHELI HOMAUN, RAISI NAFISEH, MOGHBEL A, FARJZADEH A, AGHEL N, AGHELI H,: "Evaluation of the Effect of Green Tea Extract on Mouth Bacterial Activity in the Presence of Propylene Glycol", JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, vol. 7, no. 2, 1 January 2012 (2012-01-01), pages 56 - 60, XP055877770, DOI: 10.5812/jjnpp.3588
GANESAN S: "Natural Product Radiance Traditional oral care medicinal plants survey of Tamil Nadu Introduction", TRADITIONAL ORAL CARE MEDICINAL PLANTS SURVEY OF TAMIL NADU, vol. 7, 1 April 2008 (2008-04-01), pages 166 - 172, XP055877774, ISSN: 0975-1092
| claims Claim 1: Oral Detergent Liquid type in this compound is a combination of the native micro root of the miswaak toothbrush with the extraction of nano-molecules after root crushing and conversion to nano-molecule components with the methanol extract of the brown algae sargassum glaucescens from northern coast of the Persian Gulf and the Oman Sea. They were transformed into nanoparticles after extraction through centrifuge tubes. Green tea extract and orange juice, both of which have antibacterial effects on gram-negative oral microbes, have been used to create a better flavor. An industrial sugar-free sweetener, that is plant glycerin is also used for longer shelf life. In liquid weight unit, 80% basic raw materials and 5% algae nano molecule and 1% sargassum glaucesces and 5% nano-toothbrush plus 1-2% orange and sage spring extract, 0.5 to 1% zinc throat, 1-2% Vitamin C, 1-2% Alora, 2-3% Green Tea Extract along with Allantonium were used. Claim 2: In the form of an oral gel that can be used as a toothpaste or a cleansing gel at the dentist's home or office on teeth and gum, from the combination of a native micro root film of a miswaak toothbrush with nano-molecule extraction root and conversion to nano-molecule components along with methanol extract of nano-molecule micro-particle brown alga sargassum glaucescens from the northern coast of the Persian Gulf and the Oman Sea was used to extract nano-particles after extraction through centrifuge tubes. Green tea extract, which has an antibacterial effect on gram-negative oral microbes, has been used to create a better taste and composition. An industrial sugar-free sweetener, plant glycerin, has also been used for longer shelf life. In unit weight, 70% basic toothpaste without fluoride and 5% nano-algae and 10% nano toothbrush with 5% puslane purslane extract, 1-2% orange and sage spring extract, 1-2% vitamin c, 1-2% Percentage of Alura, 2-3% of green tea extract was used along with allantonin Claim 3: According to claim 2, the nanoparticle is a brown algae microalgae on the northern coast of the Persian Gulf and a microfilm composition of the native root of the miswaak toothbrush whose particles are macroscopically visible and irregularly shaped. Claim 4: According to claim 2, purslane plant used alongside these substances has 26% vitamin A, Vitamin C 35%, magnesiuml7%, 15% manganese, 14% potassium and 11% calcium. |
| AMENDED CLAIMS received by the International Bureau on 18 October 2020 (18.10.2020) Our claims in this invention include: Claim 1: In the form of an oral gel, the compound can be used as a toothpaste or a cleansing gel at home or at work on teeth and gum. Claim 2: Explaining claim 1, by combining a micro root film of a miswaak toothbrush with nano-molecule extraction root and converting them to nano-molecule components along with methanol extract of nano-molecule micro-particle brown algae sargassum glaucescens harvested from the northern coast of the Persian Gulf and the Oman Sea, we can extract nano-particles in centrifuge tubes. Claim 3: An industrial sugar-free sweetener, herbal glycerin, has been used for longer shelf life. Claim 4: In unit weight, 70% basic toothpaste without fluoride and 5% nano-algae and 10% nano-toothbrush with 5% purslane extract, 1-2% lemon grass and sage spring extract, 1-2% vitamin C, 1-2% Percentage of Aloe vera 2-3% of green tea extract were used along with Allantonium. Claim 5: Explaining claim 2, the nanoparticle is a brown microalga obtained from the northern coast of the Persian Gulf and a microfilm composition of the native root of the miswaak toothbrush whose particles are macroscopically visible and irregularly shaped. Claim 6: Purslane has been used in the treatment of osteoporosis and psoriasis. The antioxidant content and nutritional value of purslane are important for human consumption. Referring to the usefulness of this vegetable and based on the searches done, purslane has not been used in similar toothpaste or mouthwash products so far. Claim 7: According to claim 6, We use ethanolic purslane leaves extract for protection of mouth against aphthous and destruction of skeletal bone in the root of the teeth. Claim 8: Explaining claim 7, 20% of toothpaste or mouth wash contains the ethanoic purslane leaves extract. Claim 9: Green tea extract, which has an antibacterial effect on gram-negative oral microbes, has been used to create a better taste and composition. |
Title:
Persian Gulf brown algae, Salvadora Persica microparticle and purslane extract as herbal toothpaste
Technology Field:
This invention is in the field of dental hygiene and tooth decay. To protect the teeth and gums with whitening and anti-aphthous effects.
BACKGROUND OF THE INVENTION:
Dental cavity is a high incidence despite the use of fluoride and toothpaste. Despite the benefits of fluoride for teeth and bones, fluoride itself is a toxic and dangerous substance, given that those who live near the sea get a lot of fluoride through their food and water intake, especially in children, is associated with the risks of poisoning. The existence of a safer substance that has no toxic effects but can control tooth decay has always been one of the major medical challenges. Bacteria strep mutans and actinis maceis cumitans and Candida albicans are the most important microbial agents that affect enamel production by H202, causing tooth decay and gum degradation and tooth decay and reaction due to interactions between these enamels and food residue in the mouth. The more acidic conditions in the mouth, the higher the growth and reaction environment. Bacteria itself, by producing toxins, can damage the gums and reduce bone protection in the teeth. Lack of control of the growth of oral microbes and acidic conditions in the mouth may cause tooth loss or the need for surgical treatment. Chemical and mechanical bleach or high fluoride bleaching, on the other hand, exacerbates the destructive effects of tooth enamel, which increases the number of plaque in later stages.
Algae are phototrophic substances in the marine ecosystem that provide the oxygen needed for other species. Micro-organisms have been used for many years as a rich source of food for human and animal nutrition due to their significant amounts of protein, fatty acids, carbohydrates, vitamins and minerals. Previous studies of Licheniformis bacteria living on the surface of free seaweed have been used in the preparation of toothpaste, any kind of algae used for different purposes, and the brown alga Sargassum glaucescens or the brown alga on the northern coast of the Persian Gulf have strong effects. Mutant colonies of strep mutans and actinomycosis have Coccomitens and Candida albicans.
Since ancient times, people in the Middle East have used arak root and stem from either miswaak or (salvadora persica) tooth decay and tooth whitening. The most important root, stem and leaf components of the plant include flavonoids, saponins, tannins, sulfur compounds, benzyl isothiocyanates, chloride, fluoride, calcium and silicon compounds. Fluoride, tannin, sulfur compounds and isothiocyanate compounds have a strong and widespread antimicrobial effect on a variety of microorganisms, especially streptococcus mutans, which are the major cause of dental cavities. The significant chloride in Arak toothbrush acts as a strong dentist and prevents tooth decay; therefore, people who use the tootbrush for long periods (in some Arab countries, such as Saudi Arabia) have white teeth in general. A very valuable and interesting study of the toothbrush, called benzyl isothiocyanide, showed that the body dissolves in the saliva after the toothbrush enters the mouth. It combines with an oxygen atom of hydrogen peroxide (H2 02) that results from the activity of oral microorganisms, producing ordinary water and a new compound of benzyl isothiocyanate. In this procedure, the excess oxygenated water (hydrogen peroxide) in the saliva is neutralized and reduces damage to the mucous membranes of the mouth. At the same time, a new compound of benzyl isocyanide is produced which is more potent than the disinfectant benzyl isothiocyanide.
Green tea, despite its catechin and polyphenols, greatly reduces the growth of important dental bacteria, including strep mutans and actinomycosis, and prevents gum resorption, but alone causes tooth decay.
In one study, oral purslane was used to treat oral pests, but topical use has not been applied so far.
Summary:
The basis of this invention provides a dentifrice detergent comprising a methanolic extract of the brown algae nargulaceous sargassum glaucescens from northern coast of the Persian Gulf and the Oman Sea and a native micro-molecule toothbrush in the Persian Gulf along with an extract of herbaceous and herbal tea and plant extracts and antioxidants. Nano-algae above and micro-particles of root and stem of miswaak (Arak) tree and essential oil of purslane, green tea and sage: 1) Prevent microbial growth of strep mutans, Actinis maceis and Candida albicans that cause microbial plaque. 2) Despite white effect chloride miswaak root chloride has no detrimental effect on enamel and gums 3) Along with marine minerals it strengthens dental bones 4) Purslane has strong effects on oral pests and has strong antioxidant protection against oral and esophageal mucosa.
DETAILED DESCRIPTION OF THE INVENTION:
A proprietary oral cleanser that uses the methanolic extract of the brown algae sargassum glaucescent north coast of the Oman Sea and the Persian Gulf and the stem or root of the native salvadora persica tree, also known as peelu, miswaak, neem or siwak in various parts of the world. Accompanied by purslane plant extract and green tea extract. The combination of these substances has a synergistic effect and together has a neutral chemical properties. The invention replaces fluoride-containing toothpaste and common Yemeni detergents with a combination of nano-algae and toothbrush root and purslane extract for this aim:
1- Samples of the brown algae sargassum glaucescent are isolated from the rocky northern coast of Oman and washed with sufficient fresh water to remove sand and its environmental contaminants and then for 10 days in room shade. It was dried and then powdered with an electric mill and extracted using Soxhlet method and its methanol extract was prepared. The Mill is used to make the microns.
2- The root and stem of the miswaak tree in the southern end of Iran in Bandar Abbas at the beginning of the spring season and after washing it is cut into small pieces and transformed into micro-sized ones. It is filtered to transform into 20-50 mesh components.
3- Purslane is prepared in its own season and extracted after washing.
4- Green tea extract is also made from green tea in northern Iran.
This synergistic compound with a small particle size and nano-molecular form has a less destructive effect on the gums and teeth and has a greater disinfectant effect than the consumption of individual components.
Examples of how to use this material:
Example 1
One of the materials used as a toothpaste is its powder form that can be used for every single tooth. For this purpose, after the addition of essential oils, other sweeteners such as sorbitol, orange herb and sage, which have anti-pesticide effects, and vitamin C and algae extract containing natural beta-carotene are added. Glycerin was also used to solubilize micro particles. These materials are recommended with the following percentages:
50-60% 40 mesh filtered fiber miswaak;
10-15 % nano molecule sargassum glaucescent;
1-2% nano molecule Dunaliella salina;
1-2% purslane;
3-8%sorbitol;
1-2% orange flower or garden sage extract;
1-2% green tea extract;
1-2% vitamin C;
10% Liquid vegetable glycerin solvent;
These materials are combined and heated at 60-90° C for 20-40 minutes and reconstituted. This product should be kept dry until use. Example2
The next example is the preparation of a mouthwash that can be used with or without braces. The ingredients of this compound are used by combining the above ingredients in deionized water with the addition of sorbitol-free sweeteners and sugars, and for the coloration of the red algae extract containing beta-carotene and extract of sour orange blossom. Vitamin C, alanthine, and glycerin are also used to form the fluid, which is recommended in following unit weight percentages.
20-30 % deionized water solvent;
0.1 -0.5 % nano molecule Dunaliella salina;
10-20% 40 mesh filtered fiber miswaak;
10-20 % nano molecule sargassum glaucescent;
2-30%sorbitol;
1-2% sour orange blossom extract;
1-2% green tea extract;
1-2% purslane;
0.4-1% zinc gluconate;
0.1-0.5%vitamin c;
0.1-4% allantoin
These materials are combined and heated at 60-90° C for 20-40 minutes and reconstituted. Components of this fluid should be micro-particle-sized and stored in a colloidal suspension.
This product model is recommended because it fits easily between the teeth and gums, and at least 3 minutes of gargling dissolve the toothbrush and algae components in the mouth to allow for the disinfection of oral germs.
Example 3
Our next suggestion, perhaps the most applicable, is a gel-like material that is used for brushing individual teeth, gums, and tongue. Accordingly, a vegetable gel preservative was used after preparing the main components of the material. Recommended ingredients in weight unit:
6-70% deionized water;
5-10% nano molecule sargassum glaucescent;
10-20% 40 mesh filtered fiber miswaak; 0.1-0.5 % methylparaben;
1-2% sour orange blossom or garden sage extract ;
1-2% green tea extract;
1-2% purslane;
Add sorbitol ,Moho propyl glycol; sodium lauryl sulfat surfactant; alantooin, titanium dioxide coloring; liquid vegetable glycerine solvent; carrageenan, gum xantum
Store at appropriate temperature after preparing materials and packing tube and labeling.