PH-RESPONSIVE HYDROGEL BIOCARRIER AND APPLICATION

WIPO Patent Application WO/2023/077699

A1

Disclosed in the present invention is a pH-responsive hydrogel biocarrier. The pH-responsive hydrogel biocarrier is prepared by irradiating sodium hyaluronate and methacrylic anhydride by using 365 nm ultraviolet laser in the presence of a photoinitiator, and hydroxyl on a side chain of sodium hyaluronate is polymerized into a methacrylate derivative of hyaluronic acid by means of photocrosslinking and esterification. Also disclosed in the present invention is a pH-responsive hydrogel biocarrier loaded with a therapeutic protein PDGF-BB. In the present invention, an in-situ free radical polymerization method is used for synthesis, a reaction condition is mild, and biological activity of PDGF-BB is not influenced; and PDGF-BB is wrapped in the hydrogel, preventing the expose in an enzyme environment, and improving the stability of the biological activity of PDGF-BB.

JPH0621137	[Title of Invention] Polyester-based acrylic resin composition
JPH0680089	[Title of Invention] Method for Producing Photocurable Polymer

ZHAO XINGHUI (CN)
ZHAI JUNHUI (CN)
DU HONG (CN)
WANG KELONG (CN)

PCT/CN2022/079518

May 11, 2023

March 07, 2022

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BIO BANK CORP (CN)

C08F299/00; A61K9/06; A61K38/18; A61K47/36; A61P17/02; C08F2/48; C08F222/20; C08F251/00

CN113736043A	2021-12-03
CN111592618A	2020-08-28
CN104231288A	2014-12-24
EP3235514A1	2017-10-25

WANG, YASHI ET AL.: "“A dual receptors-targeting and size-switchable “cluster bomb” co-loading chemotherapeutic and transient receptor potential ankyrin 1 (TRPA-1) inhibitor for treatment of triple negative breast cancer”", JOURNAL OF CONTROLLED RELEASE, vol. 321, 5 February 2020 (2020-02-05), XP086135620, DOI: 10.1016/j.jconrel.2020.02.010

BEIJING ZHONGTIAN LAWFIRM (CN)

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