Title:
PH-SENSITIVE FLUOROPHORES
Document Type and Number:
WIPO Patent Application WO/2023/147196
Kind Code:
A3
Abstract:
The present application provides pH-sensitive fluorophores, pharmaceutical compositions comprising pH-sensitive fluorophores, and methods for imaging of cancerous tumors comprising administering to the subject an effective amount of a compound or a pharmaceutical composition, waiting a time sufficient to allow the compound to accumulate in the cancerous tumor to be imaged, and imaging the cancerous tumor with a fluorescence imaging technique. Further provided methods of treating cancer, comprising imaging a cancerous tumor in a subject; and surgically removing the cancerous tumor from the subject.
Inventors:
CHOI HAK SOO (US)
KASHIWAGI SATOSHI (US)
HENARY MAGED (US)
KASHIWAGI SATOSHI (US)
HENARY MAGED (US)
Application Number:
PCT/US2023/012049
Publication Date:
September 28, 2023
Filing Date:
January 31, 2023
Export Citation:
Assignee:
MASSACHUSETTS GEN HOSPITAL (US)
UNIV GEORGIA STATE RES FOUND (US)
UNIV GEORGIA STATE RES FOUND (US)
International Classes:
A61K31/4045; A61B5/00; C09B11/22; C09B23/02; G01N21/64; A61P35/00
Domestic Patent References:
| WO2021026402A1 | 2021-02-11 | |||
| WO2010091243A1 | 2010-08-12 |
Foreign References:
| US20100285515A1 | 2010-11-11 | |||
| US20180147303A1 | 2018-05-31 |
Other References:
NJIOJOB COSTYL N., OWENS ERIC A., NARAYANA LAKSHMINARAYANA, HYUN HOON, CHOI HAK SOO, HENARY MAGED: "Tailored Near-Infrared Contrast Agents for Image Guided Surgery", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 58, no. 6, 26 March 2015 (2015-03-26), US , pages 2845 - 2854, XP093096952, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.5b00253
OWENS ERIC A., HENARY MAGED, EL FAKHRI GEORGES, CHOI HAK SOO: "Tissue-Specific Near-Infrared Fluorescence Imaging", ACCOUNTS OF CHEMICAL RESEARCH, ACS , WASHINGTON , DC, US, vol. 49, no. 9, 20 September 2016 (2016-09-20), US , pages 1731 - 1740, XP093096953, ISSN: 0001-4842, DOI: 10.1021/acs.accounts.6b00239
YOKOMIZO SHINYA, HENARY MAGED, BUABENG EMMANUEL R., FUKUDA TAKESHI, MONACO HAILEY, BAEK YOONJI, MANGANIELLO SOPHIA, WANG HAORAN, K: "Topical pH Sensing NIR Fluorophores for Intraoperative Imaging and Surgery of Disseminated Ovarian Cancer", ADVANCED SCIENCE, vol. 9, no. 20, 1 July 2022 (2022-07-01), XP093096954, ISSN: 2198-3844, DOI: 10.1002/advs.202201416
OWENS ERIC A., HENARY MAGED, EL FAKHRI GEORGES, CHOI HAK SOO: "Tissue-Specific Near-Infrared Fluorescence Imaging", ACCOUNTS OF CHEMICAL RESEARCH, ACS , WASHINGTON , DC, US, vol. 49, no. 9, 20 September 2016 (2016-09-20), US , pages 1731 - 1740, XP093096953, ISSN: 0001-4842, DOI: 10.1021/acs.accounts.6b00239
YOKOMIZO SHINYA, HENARY MAGED, BUABENG EMMANUEL R., FUKUDA TAKESHI, MONACO HAILEY, BAEK YOONJI, MANGANIELLO SOPHIA, WANG HAORAN, K: "Topical pH Sensing NIR Fluorophores for Intraoperative Imaging and Surgery of Disseminated Ovarian Cancer", ADVANCED SCIENCE, vol. 9, no. 20, 1 July 2022 (2022-07-01), XP093096954, ISSN: 2198-3844, DOI: 10.1002/advs.202201416
Attorney, Agent or Firm:
IGNATENKO, Vasily, A. et al. (US)
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