Title:
PHAGE DISPLAY LIBRARIES OF HUMAN VH FRAGMENTS
Document Type and Number:
WIPO Patent Application WO2002051870
Kind Code:
A3
Abstract:
Phage display libraries are taught in which the recombinant phage population displays a plurality of potential binding fragments having preferred characteristics of solubility and/or intermolecular interaction. Also taught are methods of biasing display libraries to produce variants which more closely approximate the preferred characteristics of the parental binding fragment.
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Inventors:
ENTWISTLE JOCELYN (CA)
TANHA JAMSHID (CA)
NARANG SARAN (CA)
DAN MICHAEL (CA)
MACKENZIE COLIN R (CA)
TANHA JAMSHID (CA)
NARANG SARAN (CA)
DAN MICHAEL (CA)
MACKENZIE COLIN R (CA)
Application Number:
PCT/CA2001/001845
Publication Date:
April 24, 2003
Filing Date:
December 21, 2001
Export Citation:
Assignee:
GRAD CAROLE (CA)
ENTWISTLE JOCELYN (CA)
TANHA JAMSHID (CA)
NARANG SARAN (CA)
DAN MICHAEL (CA)
MACKENZIE COLIN R (CA)
ENTWISTLE JOCELYN (CA)
TANHA JAMSHID (CA)
NARANG SARAN (CA)
DAN MICHAEL (CA)
MACKENZIE COLIN R (CA)
International Classes:
C07K16/00; C07K16/30; C12N15/10; C40B40/02; (IPC1-7): C07K16/00; C12N15/10
Domestic Patent References:
| WO2000029004A1 | 2000-05-25 | |||
| WO2001018058A2 | 2001-03-15 |
Other References:
ARBABI GHAHROUDI M ET AL: "Selection and identification of single domain antibody fragments from camel heavy-chain antibodies", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 414, no. 3, 15 September 1997 (1997-09-15), pages 521 - 526, XP002105421, ISSN: 0014-5793
RIECHMANN L ET AL: "Single domain antibodies: comparison of camel VH and camelised human VH domains", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 231, no. 1-2, 10 December 1999 (1999-12-10), pages 25 - 38, XP004187632, ISSN: 0022-1759
DAVIES J ET AL: "SINGLE ANTIBODY DOMAINS AS SMALL RECOGNITION UNITS: DESIGN AND IN VITRO ANTIGEN SELECTION OF CAMELIZED, HUMAN VH DOMAINS WITH IMPROVED PROTEIN STABILITY", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 9, no. 6, 1996, pages 531 - 537, XP000971767, ISSN: 0269-2139
RIECHMANN L ET AL: "Single domain antibodies: comparison of camel VH and camelised human VH domains", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 231, no. 1-2, 10 December 1999 (1999-12-10), pages 25 - 38, XP004187632, ISSN: 0022-1759
DAVIES J ET AL: "SINGLE ANTIBODY DOMAINS AS SMALL RECOGNITION UNITS: DESIGN AND IN VITRO ANTIGEN SELECTION OF CAMELIZED, HUMAN VH DOMAINS WITH IMPROVED PROTEIN STABILITY", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 9, no. 6, 1996, pages 531 - 537, XP000971767, ISSN: 0269-2139
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