Title:
PHARMACEUTICAL COMBINATION COMPRISING AN ANTI-ANDROGEN AND AN OESTROGEN RECEPTOR BETA AGONIST
Document Type and Number:
WIPO Patent Application WO2002092129
Kind Code:
A3
Abstract:
The present invention relates to a pharmaceutical product or daily dose comprising an anti-androgen, an oestrogen receptor beta (ER beta ) selective agonist and optionally a chemical castration agent. The invention also relates to a method of therapeutically treating and/or preventing an androgen-stimulated disease (eg, prostate cancer or benign prostate hypertrophy) in a patient. Furthermore, the invention relates to the use of an anti-androgen, an ER beta selective agonist and optionally a chemical castration agent in the manufacture of a pharmaceutical product for this purpose.
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Inventors:
FURR BARRINGTON JOHN ALBERT (GB)
BROOKS ANTHONY NIGEL (GB)
VEALE CHRIS ALLAN (US)
BROOKS ANTHONY NIGEL (GB)
VEALE CHRIS ALLAN (US)
Application Number:
PCT/GB2002/002125
Publication Date:
February 27, 2003
Filing Date:
May 08, 2002
Export Citation:
Assignee:
ASTRAZENECA AB (SE)
ASTRAZENECA UK LTD (GB)
FURR BARRINGTON JOHN ALBERT (GB)
BROOKS ANTHONY NIGEL (GB)
VEALE CHRIS ALLAN (US)
ASTRAZENECA UK LTD (GB)
FURR BARRINGTON JOHN ALBERT (GB)
BROOKS ANTHONY NIGEL (GB)
VEALE CHRIS ALLAN (US)
International Classes:
C07D233/72; A61K31/165; A61K31/167; A61K31/4166; A61K31/57; A61K38/00; A61K45/06; A61P5/28; A61P5/30; A61P13/08; A61P17/00; A61P17/10; A61P35/00; (IPC1-7): A61K45/06; A61P5/28; A61P5/30
Domestic Patent References:
| WO1998048790A1 | 1998-11-05 | |||
| WO1999008668A2 | 1999-02-25 |
Foreign References:
| GB2361642A | 2001-10-31 | |||
| US4760053A | 1988-07-26 |
Other References:
ROSENBERG ZAND, R. ET AL.: "Genistein: a potent natural antiandrogen", CLINICAL CHEMISTRY, vol. 46, no. 6, 2000, pages 887 - 888, XP002220308
GELLER J ET AL: "GENISTEIN INHIBITS THE GROWTH OF HUMAN-PATIENT BPH AND PROSTATE CANCER IN HISTOCULTURE", PROSTATE, WILEY-LISS, NEW YORK, NY, US, vol. 2, no. 34, 1 February 1998 (1998-02-01), pages 75 - 79, XP002077078, ISSN: 0270-4137
SANTIBANEZ J F ET AL: "GENISTEIN INHIBITS PROLIFERATION AND IN VITRO INVASIVE POTENTIAL OF HUMAN PROSTATIC CANCER CELL LINES", ANTICANCER RESEARCH, HELENIC ANTICANCER INSTITUTE, ATHENS,, GR, vol. 2A, no. 17, 1 March 1997 (1997-03-01), pages 1199 - 1204, XP002077081, ISSN: 0250-7005
BOSLAND M C ET AL: "INHIBITION OF HUMAN PROSTATE CANCER CELL PROLIFERATION BY GENISTEIN", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, NEW YORK, NY, US, no. 38, 1 March 1997 (1997-03-01), pages 262, XP002077080, ISSN: 0197-016X
DATABASE WPI Derwent World Patents Index; AN 2001-420779, XP002220310, TAMUTA, A. AND ISHIWATARI, K.: "Food compositions containing Vitex agnus-castus friuts and isoflavones, useful remedies for premenstrual syndrome and female post puberal acne"
GELLER J ET AL: "GENISTEIN INHIBITS THE GROWTH OF HUMAN-PATIENT BPH AND PROSTATE CANCER IN HISTOCULTURE", PROSTATE, WILEY-LISS, NEW YORK, NY, US, vol. 2, no. 34, 1 February 1998 (1998-02-01), pages 75 - 79, XP002077078, ISSN: 0270-4137
SANTIBANEZ J F ET AL: "GENISTEIN INHIBITS PROLIFERATION AND IN VITRO INVASIVE POTENTIAL OF HUMAN PROSTATIC CANCER CELL LINES", ANTICANCER RESEARCH, HELENIC ANTICANCER INSTITUTE, ATHENS,, GR, vol. 2A, no. 17, 1 March 1997 (1997-03-01), pages 1199 - 1204, XP002077081, ISSN: 0250-7005
BOSLAND M C ET AL: "INHIBITION OF HUMAN PROSTATE CANCER CELL PROLIFERATION BY GENISTEIN", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, NEW YORK, NY, US, no. 38, 1 March 1997 (1997-03-01), pages 262, XP002077080, ISSN: 0197-016X
DATABASE WPI Derwent World Patents Index; AN 2001-420779, XP002220310, TAMUTA, A. AND ISHIWATARI, K.: "Food compositions containing Vitex agnus-castus friuts and isoflavones, useful remedies for premenstrual syndrome and female post puberal acne"
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