Title:
PHARMACEUTICAL COMBINATION COMPRISING GLYCOLIC ACID AND L-ALANINE OR PYRUVATE
Document Type and Number:
WIPO Patent Application WO/2022/023545
Kind Code:
A3
Abstract:
The invention relates to a pharmaceutical combination, comprising glycolic acid or a pharmaceutically acceptable salt or ester thereof, and L-alanine and/or pyruvate, or a pharmaceutically acceptable salt thereof. The combination of the invention optionally comprises D-lactate and/or phenylbutyrate and/or tauroursodeoxycholic acid, or pharmaceutically acceptable salts or esters thereof. Further aspects of the invention relate to the combination of the invention for use in the treatment of neurological medical conditions, for stimulating neuronal plasticity, for regulating intracellular calcium and/or for stimulating mitochondrial function and ATP production, thereby enabling a slowing, reversing and/or inhibiting of the ageing process and/or regulating, preferably stimulating, the immune system.
Inventors:
PAN-MONTOJO FRANCISCO (DE)
Application Number:
PCT/EP2021/071431
Publication Date:
April 21, 2022
Filing Date:
July 30, 2021
Export Citation:
Assignee:
PAN MONTOJO FRANCISCO (DE)
International Classes:
A61K31/198; A61K31/19; A61P9/10; A61P15/08; A61P25/28; A61P37/04
Domestic Patent References:
| WO2019038655A1 | 2019-02-28 |
Foreign References:
| CN108866103A | 2018-11-23 | |||
| US20170239201A1 | 2017-08-24 | |||
| US20170326085A1 | 2017-11-16 |
Other References:
Y. TOYODA ET AL: "Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival", BIOLOGY OPEN, vol. 3, no. 8, 25 July 2014 (2014-07-25), pages 777 - 784, XP055331047, DOI: 10.1242/bio.20149399
MORITA NAOKI ET AL: "GPR31-dependent dendrite protrusion of intestinal CX3CR1+cells by bacterial metabolites", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 566, no. 7742, 23 January 2019 (2019-01-23), pages 110 - 114, XP036693116, ISSN: 0028-0836, [retrieved on 20190123], DOI: 10.1038/S41586-019-0884-1
MORITA NAOKI ET AL: "GPR31-dependent dendrite protrusion of intestinal CX3CR1+cells by bacterial metabolites", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 566, no. 7742, 23 January 2019 (2019-01-23), pages 110 - 114, XP036693116, ISSN: 0028-0836, [retrieved on 20190123], DOI: 10.1038/S41586-019-0884-1
Attorney, Agent or Firm:
HERTIN UND PARTNER RECHTS- UND PATENTANWÄLTE (DE)
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