Title:
PHARMACEUTICAL COMBINATION FOR TREATING TUMORS AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/136523
Kind Code:
A1
Abstract:
Provided are a pharmaceutical combination for treating tumors and an application thereof. The pharmaceutical combination comprises a compound represented by formula A, a pharmaceutically acceptable salt thereof, a solvate thereof or a solvate of a pharmaceutically acceptable salt thereof, and a "PD-1 inhibitor and/or PD-L1 inhibitor". The components of the pharmaceutical combination, when used in combination, can significantly increase the inhibition rate of each individual drug on tumor growth, and there were no acute adverse reactions in mice after administration, demonstrating that such a combination therapy has good safety and effectiveness.
Inventors:
SHEN XIAOKUN (CN)
LI ZENG (CN)
LI ZENG (CN)
Application Number:
PCT/CN2020/142257
Publication Date:
July 08, 2021
Filing Date:
December 31, 2020
Export Citation:
Assignee:
FUKANG SHANGHAI HEALTH TECH CO LTD (CN)
International Classes:
A61K31/343; A61K39/395; A61P35/00; C07D307/81
Domestic Patent References:
| WO2019152989A1 | 2019-08-08 | |||
| WO2019152989A1 | 2019-08-08 | |||
| WO2013117120A1 | 2013-08-15 |
Foreign References:
| CN103242273A | 2013-08-14 | |||
| CN103242273A | 2013-08-14 | |||
| CN102627620A | 2012-08-08 | |||
| CN102627620A | 2012-08-08 | |||
| CN110382545A | 2019-10-25 | |||
| CN110382545A | 2019-10-25 | |||
| CN201911417368A | 2019-12-31 |
Other References:
SHIPING JIAO, WEIYA XIA, HIROHITO YAMAGUCHI, YONGKUN WEI, MEI-KUANG CHEN, JUNG-MAO HSU, JENNIFER L. HSU, WEN-HSUAN YU, YI DU, HENG: "PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression", CLINICAL CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 23, no. 14, 15 July 2017 (2017-07-15), US, pages 3711 - 3720, XP055567673, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-16-3215
SHIPING JIAO, WEIYA XIA, HIROHITO YAMAGUCHI, YONGKUN WEI, MEI-KUANG CHEN, JUNG-MAO HSU, JENNIFER L. HSU, WEN-HSUAN YU, YI DU, HENG: "PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression", CLINICAL CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 23, no. 14, 15 July 2017 (2017-07-15), US, pages 3711 - 3720, XP055567673, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-16-3215
BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
"Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
See also references of EP 4085908A4
SHIPING JIAO, WEIYA XIA, HIROHITO YAMAGUCHI, YONGKUN WEI, MEI-KUANG CHEN, JUNG-MAO HSU, JENNIFER L. HSU, WEN-HSUAN YU, YI DU, HENG: "PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression", CLINICAL CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 23, no. 14, 15 July 2017 (2017-07-15), US, pages 3711 - 3720, XP055567673, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-16-3215
BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
"Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
See also references of EP 4085908A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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