Title:
PHARMACEUTICAL COMBINATION
Document Type and Number:
WIPO Patent Application WO/2007/102531
Kind Code:
A1
Abstract:
Disclosed is a pharmaceutical combination comprising a calcium receptor modulator and a bone resorption inhibitor, wherein the calcium receptor modulator comprises a compound represented by the formula (I) or a salt thereof or a prodrug of the compound or the salt. (I) wherein the ring A represents a 5- to 7-membered ring which may be substituted; the ring B represents a 5- to 7-membered heterocyclic ring which may be substituted; X1 represents CR1 (wherein R1 represents a hydrogen, a hydrocarbon group which may be substituted, or the like) or the like; X2 represents N or the like; Y represents C or the like; Ar represents a cyclic group which may be substituted; R represents a hydrocarbon group which may be substituted or the like; and (a) represents a single or double bond.
Inventors:
NOTOYA KOHEI (JP)
OKA MASAHIRO (JP)
OKA MASAHIRO (JP)
Application Number:
PCT/JP2007/054398
Publication Date:
September 13, 2007
Filing Date:
March 07, 2007
Export Citation:
Assignee:
TAKEDA PHARMACEUTICAL (JP)
NOTOYA KOHEI (JP)
OKA MASAHIRO (JP)
NOTOYA KOHEI (JP)
OKA MASAHIRO (JP)
International Classes:
A61K31/519; A61K45/00; A61P1/00; A61P13/12; A61P19/00; A61P25/00; A61P43/00; C07D487/04
Domestic Patent References:
| WO2004017908A2 | 2004-03-04 | |||
| WO2004106280A1 | 2004-12-09 | |||
| WO2005030749A1 | 2005-04-07 | |||
| WO2005000502A1 | 2005-01-06 |
Foreign References:
| JP2005239611A | 2005-09-08 | |||
| JP2004519428A | 2004-07-02 | |||
| JP2004519428A | 2004-07-02 |
Other References:
NATURE, vol. 366, 1993, pages 575 - 580
BONE, vol. 20, 1997, pages 303 - 309
KIDNEY INT, vol. 50, 1996, pages 2129 - 2139
BRAIN RES, vol. 744, 1997, pages 47 - 56
DEVELOP BRAIN RES, vol. 100, 1997, pages 13 - 21
MOL ENDOCRINOL, vol. 10, 1996, pages 555 - 565
J. CLIN INVEST, vol. 99, 1997, pages 2328 - 2333
BIOCHEM BIOPHYS RES COMMUM, vol. 232, 1997, pages 80 - 83
HIROKAWA SHOTEN: "Molecular Design", vol. 7, 1990, article "Development of Drugs", pages: 163 - 198
JOURNAL OF CLINICAL ONCOLOGY, vol. 12, 1994, pages 213 - 225
BRITISH JOURNAL OF CANCER, vol. 68, 1993, pages 314 - 318
See also references of EP 1992348A4
BONE, vol. 20, 1997, pages 303 - 309
KIDNEY INT, vol. 50, 1996, pages 2129 - 2139
BRAIN RES, vol. 744, 1997, pages 47 - 56
DEVELOP BRAIN RES, vol. 100, 1997, pages 13 - 21
MOL ENDOCRINOL, vol. 10, 1996, pages 555 - 565
J. CLIN INVEST, vol. 99, 1997, pages 2328 - 2333
BIOCHEM BIOPHYS RES COMMUM, vol. 232, 1997, pages 80 - 83
HIROKAWA SHOTEN: "Molecular Design", vol. 7, 1990, article "Development of Drugs", pages: 163 - 198
JOURNAL OF CLINICAL ONCOLOGY, vol. 12, 1994, pages 213 - 225
BRITISH JOURNAL OF CANCER, vol. 68, 1993, pages 314 - 318
See also references of EP 1992348A4
Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (IMP Building 3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka 01, JP)
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