Title:
PHARMACEUTICAL COMPOSITION COMPRISING ACTIVATED T CELLS SPECIFIC TO K-RAS FOR PREVENTING AND TREATING LUNG PAPILLARY ADENOCARCINOMA AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2023/128377
Kind Code:
A1
Abstract:
A pharmaceutical composition comprising activated T cells specific to K-ras for preventing and treating lung papillary adenocarcinoma, according to the present invention, uses, as an antigen composition, a K-ras mutant (G12D, G12V, and G13D) recombinant overlapping peptide, which is designed such that a total of 12 epitopes (n= 1 to 12, and the last epitope (n=12) consists of 23 amino acids) in units of 30 amino acids sequentially in the amino acid sequence of K-ras are distinguished, and the sequence of 15 amino acids overlaps between the epitopes. Accordingly, the pharmaceutical composition has an advantageous effect of recognizing and killing lung papillary adenocarcinoma in which K-ras, K-ras mutant G12V, K-ras mutant G12D, or K-ras mutant G13D is detected. Accordingly, the use of the pharmaceutical composition comprising activated T cells specific to K-ras for preventing and treating lung papillary adenocarcinoma of the present invention has the advantage of effectively preventing and treating lung adenocarcinoma, particularly lung papillary adenocarcinoma, in which K-ras as well as K-ras mutants are detected,.
Inventors:
LEE WANG JUN (KR)
MOON HYOUN JONG (KR)
LIM SUN KI (KR)
MOON HYOUN JONG (KR)
LIM SUN KI (KR)
Application Number:
PCT/KR2022/019961
Publication Date:
July 06, 2023
Filing Date:
December 08, 2022
Export Citation:
Assignee:
MYONGJI HOSPITAL (KR)
International Classes:
A61K35/17; A61P35/00; C12N5/0783
Foreign References:
| KR20170122270A | 2017-11-03 | |||
| KR20180081532A | 2018-07-16 | |||
| KR20170096199A | 2017-08-23 | |||
| CN112646024A | 2021-04-13 | |||
| CN112300269A | 2021-02-02 |
Other References:
DATABASE Protein 2 May 1996 (1996-05-02), ANONYMOUS : "protein Calu1 Ki-ras ", XP093074275, retrieved from NCBI Database accession no. 0909261A
DATABASE Protein 19 January 2018 (2018-01-19), ANONYMOUS : "GTPase KRas isoform X3 [Cavia porcellus] ", XP093074300, retrieved from NCBI Database accession no. XP_003470499.2
DATABASE Protein 19 January 2018 (2018-01-19), ANONYMOUS : "GTPase KRas isoform X3 [Cavia porcellus] ", XP093074300, retrieved from NCBI Database accession no. XP_003470499.2
Attorney, Agent or Firm:
KIM, Jeong Hyeon (KR)
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